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A tug-of-war between driver and passenger mutations in cancer and other adaptive processes

bioRxiv

Feb 26, 2014

Christopher D McFarlandKirill S Korolev

Abstract

Cancer progression is an example of a rapid adaptive process where evolving new traits is essential for survival and requires a high mutation rate. Precancerous cells acquire a few key mutations that drive rapid population growth and carcinogenesis. Cancer genomics demonstrates that the...read more

Mentioned in this Paper

EAF2 gene
Premalignant Cell
Mutation Abnormality
Disease Progression
Mutagenicity Tests
Neoplasms
Cancer Progression
Research
Tumor Cells, Malignant
Treatment Protocols
9
4
Paper Details
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A tug-of-war between driver and passenger mutations in cancer and other adaptive processes

bioRxiv

Feb 26, 2014

Christopher D McFarlandKirill S Korolev

PMID: 990003053

DOI: 10.1101/003053

Abstract

Cancer progression is an example of a rapid adaptive process where evolving new traits is essential for survival and requires a high mutation rate. Precancerous cells acquire a few key mutations that drive rapid population growth and carcinogenesis. Cancer genomics demonstrates that the...read more

Mentioned in this Paper

EAF2 gene
Premalignant Cell
Mutation Abnormality
Disease Progression
Mutagenicity Tests
Neoplasms
Cancer Progression
Research
Tumor Cells, Malignant
Treatment Protocols
9
4
Paper Details
References
  • References
  • Citations
  • finger pointing at paper

    References currently unavailable

    We're still populating references for this paper, please check back later.
  • References
  • Citations
  • quote and clock

    No citations available

    This paper may not have been cited yet.
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