A Tumor Cell-Intrinsic Yin-Yang Determining Immune Evasion

Immunity
Brendan Horton, Stefani Spranger

Abstract

Pancreatic adenocarcinoma (PDAC) is mostly refractory to immunotherapies. In this issue of Immunity, Li et al. (2018) generate a library of clonal PDAC tumors to examine the tumor-intrinsic features shaping the anti-tumor immune response and find that tumor cell-derived CXCL1 directly blunts T cell infiltration and reduces responsiveness to immunotherapy.

Citations

Oct 21, 2018·Genes and Immunity·Giuseppe RaschellàAlessandra Gambacurta
Mar 27, 2019·Medicinal Research Reviews·Qinghua WuKamil Kuca
Mar 25, 2019·Oncoimmunology·Pranav MurthyMichael T Lotze
Oct 4, 2020·Journal of Hematology & Oncology·Yunzhen QianChen Liu
May 22, 2021·Human Vaccines & Immunotherapeutics·Andrew GeorgeWafik S El-Deiry

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