A tumor-immune interaction model for hepatocellular carcinoma based on measured lymphocyte counts in patients undergoing radiotherapy.

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
Wonmo SungHarald Paganetti

Abstract

The impact of radiation therapy on the immune system has recently gained attention particularly when delivered in combination with immunotherapy. However, it is unclear how different treatment fractionation regimens influence the interaction between the immune system and radiation. The goal of this work was to develop a mathematical model that quantifies both the immune stimulating as well as the immunosuppressive effects of radiotherapy and simulates the effects of different fractionation regimens based on patient data. The framework describes the temporal evolution of tumor cells, lymphocytes, and inactivated dying tumor cells releasing antigens during radiation therapy, specifically modeling how recruited lymphocytes inhibit tumor progression. The parameters of the model were partly taken from the literature and in part extracted from blood samples (circulating lymphocytes: CLs) collected from hepatocellular carcinoma patients undergoing radiotherapy and their outcomes. The dose volume histograms to circulating lymphocytes were calculated with a probability-based model. Based on the fitted parameters, the model enabled a study into the depletion and recovery of CLs in patients as a function of fractionation regimen. Our resu...Continue Reading

References

Oct 19, 1999·International Journal of Radiation Oncology, Biology, Physics·I F CiernikD P Carbone
Aug 23, 2001·International Journal of Radiation Oncology, Biology, Physics·C M WestR D Hunter
Jul 27, 2007·Mathematical Medicine and Biology : a Journal of the IMA·D Rodríguez-PérezJ C Antoranz
Feb 12, 2008·International Journal of Radiation Oncology, Biology, Physics·An TaiX Allen Li
Jul 9, 2009·Mathematical Medicine and Biology : a Journal of the IMA·O Sotolongo-GrauJ C Antoranz
Aug 27, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·M Zahidunnabi DewanSandra Demaria
Nov 24, 2012·Molecular Cancer Research : MCR·Adeola Y MakindeC Norman Coleman
Jul 19, 2013·The Journal of Clinical Investigation·Anusha KalbasiNeha Vapiwala
Aug 14, 2015·JAMA Oncology·Sandra DemariaSilvia C Formenti
Dec 17, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Theodore S HongAndrew X Zhu
Jan 21, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Alexander MartensBenjamin Weide
Feb 13, 2016·International Journal of Radiation Oncology, Biology, Physics·Aaron T WildSusannah G Ellsworth
Jun 16, 2016·Cancer Research·Raphael SerreDominique Barbolosi
Aug 9, 2016·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Ilinca PoppDan G Duda
Dec 17, 2016·International Journal of Radiation Oncology, Biology, Physics·Clemens GrassbergerHarald Paganetti
Dec 27, 2016·Science Immunology·Michael SpiottoRalph R Weichselbaum
Jun 10, 2017·Nature Communications·Claire Vanpouille-BoxSandra Demaria
Aug 18, 2017·International Journal of Radiation Oncology, Biology, Physics·Rajayogesh DavuluriSteven H Lin
Jun 4, 2018·International Journal of Radiation Oncology, Biology, Physics·Clemens GrassbergerDan G Duda
Aug 31, 2018·Oncotarget·Raphaël SerreDominique Barbolosi
Nov 2, 2018·International Journal of Molecular Sciences·Jan Poleszczuk, Heiko Enderling
Jan 27, 2019·International Journal of Radiation Oncology, Biology, Physics·Nina N SanfordTheodore S Hong
Feb 2, 2019·Advances in Radiation Oncology·David M RoutmanKenneth W Merrell
Apr 10, 2019·JCO Clinical Cancer Informatics·Juan Carlos López AlfonsoHeiko Enderling
Apr 22, 2019·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Ali AjdariThomas Bortfeld
Mar 3, 2020·Physics in Medicine and Biology·Abdelkhalek HammiClemens Grassberger

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Citations

Dec 10, 2020·Journal of Clinical Medicine·Arkadz KirshteinLeili Shahriyari
Mar 5, 2021·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Cynthia Terrones-CamposJens Lundgren
Apr 18, 2021·Nature Biomedical Engineering·Clemens Grassberger, Wilfred Ngwa

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