A tumor-immune mathematical model of CD4+ T helper cell dependent tumor regression by oncogene inactivation

Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Chinyere I NwabugwuDavid S Paik

Abstract

Understanding the complex dynamics between the tumor cells and the host immune system will be key to improved therapeutic strategies against cancer. We propose an ODE-based mathematical model of both the tumor and immune system and how they respond to inactivation of the driving oncogene. Our model supports experimental results showing that cellular senescence of tumor cells is dependent on CD4+ T helper cells, leading to relapse of tumors in immunocompromised hosts.

Related Concepts

Tumor Cells, Uncertain Whether Benign or Malignant
Immune System
Cell Aging
Neoplasms
Helper-Inducer T-Lymphocyte
CD4 Positive T Lymphocytes
Malignant Neoplasms
Entire Immune System
Oncogenes
Inactivation

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