A tumor suppressor role for thyroid hormone beta receptor in a mouse model of thyroid carcinogenesis

Endocrinology
Yasuhito KatoSheue-Yann Cheng

Abstract

We have created a knockin mutant mouse by targeting a mutation (PV) into the thyroid hormone receptor beta gene (TRbetaPV mouse). TRbetaPV/PV mice, but not TRbetaPV/+ mice, spontaneously develop follicular thyroid carcinoma. To identify other genetic changes in the TRbeta gene that could also induce thyroid carcinoma, we crossed TRbetaPV mice with TRbeta-/- mice. As TRbetaPV/- mice (mutation of one TRbeta allele in the absence of the other wild-type allele) aged, they also spontaneously developed follicular thyroid carcinoma through the pathological progression of hyperplasia, capsular and vascular invasion, anaplasia, and eventually metastasis to the lung, but not to the lymph nodes. The pathological progression of thyroid carcinoma in TRbetaPV/- mice was indistinguishable from that in TRbetaPV/PV mice. Analyses of the expression patterns of critical genes indicated activation of the signaling pathways mediated by TSH, peptide growth factors (epidermal growth factor and fibroblast growth factor), TGF-beta, TNF-alpha, and nuclear factor-kappaB, and also suggested progressive repression of the pathways mediated by the peroxisome proliferator-activated receptor gamma. The patterns in the alteration of these signaling pathways are...Continue Reading

References

Oct 25, 1994·Proceedings of the National Academy of Sciences of the United States of America·F M MichielsJ Feunteun
Oct 26, 1999·Endocrine Reviews·B Desvergne, W Wahli
Apr 6, 2000·Journal of Molecular Endocrinology·F WangS H Safe
May 24, 2000·Cancer Letters·M Puzianowska-KuznickaJ Nauman
Nov 9, 2000·Proceedings of the National Academy of Sciences of the United States of America·M KaneshigeS Cheng
May 1, 2001·Thyroid : Official Journal of the American Thyroid Association·J D SaferF E Wondisford
Jun 27, 2001·Trends in Genetics : TIG·T E AkiyamaF J Gonzalez
Jun 28, 2001·Physiological Reviews·P M Yen
Nov 10, 2001·The Journal of Clinical Endocrinology and Metabolism·S AndoP M Yen
Nov 14, 2001·Reviews in Endocrine & Metabolic Disorders·R E Weiss, S Refetoff
Mar 13, 2002·The Journal of Clinical Endocrinology and Metabolism·Monika Puzianowska-KuznickaJanusz Nauman
Aug 8, 2002·Thyroid : Official Journal of the American Thyroid Association·Clare B Harvey, Graham R Williams
Dec 20, 2002·Thyroid : Official Journal of the American Thyroid Association·Hideyo SuzukiSheue-Yann Cheng
Jul 5, 2003·The Journal of Clinical Endocrinology and Metabolism·Toru TakanoNobuyuki Amino
Aug 30, 2003·Trends in Endocrinology and Metabolism : TEM·Paul M Yen

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Citations

Apr 10, 2009·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·X-G Zhu, S-Y Cheng
Dec 17, 2009·Thyroid : Official Journal of the American Thyroid Association·Caroline S Kim, Xuguang Zhu
Feb 10, 2012·The Journal of Clinical Endocrinology and Metabolism·Alfonso Massimiliano FerraraSamuel Refetoff
Jul 4, 2013·Thyroid : Official Journal of the American Thyroid Association·Landon WarkThomas Klonisch
Jul 16, 2011·Journal of Thyroid Research·Meghan D Rosen, Martin L Privalsky
Jan 23, 2016·Frontiers in Endocrinology·Helen Louise Robbins, Angela Hague
Jul 1, 2015·Molecular and Cellular Endocrinology·Lawrence S KirschnerAmruta Ashtekar
Nov 26, 2009·Molecular and Cellular Endocrinology·Beatriz C G Freitas, Janete M Cerutti
Aug 17, 2005·Cancer Genetics and Cytogenetics·Drazen B ZimonjicSheue-Yann Cheng
Apr 30, 2005·Trends in Endocrinology and Metabolism : TEM·Sheue-yann Cheng
Aug 13, 2013·Molecular and Cellular Endocrinology·Dang Vu-Phan, Ronald J Koenig
Apr 18, 2012·Biochimica Et Biophysica Acta·Won Gu Kim, Sheue-yann Cheng
Jun 30, 2016·Endocrine-related Cancer·Andrea PerraAmedeo Columbano
Jun 8, 2017·Cell Metabolism·Christopher HineJames R Mitchell
Jan 2, 2007·Veterinary Pathology·K A B KnostmanC C Capen
Nov 27, 2018·The Journal of Endocrinology·Manuel D GaheteRaul M Luque
Jul 9, 2005·Endocrinology·Caroline S KimMatthew D Ringel
Nov 1, 2006·Expert Review of Endocrinology & Metabolism·Paul J DavisMichael J Ciesielski
Dec 21, 2017·International Journal of Molecular Sciences·Adelaide GrecoMarcello Mancini
Jan 1, 2007·Expert Review of Endocrinology & Metabolism·Sheue-Yann Cheng
Jan 31, 2006·Arquivos brasileiros de endocrinologia e metabologia·Rui M B MacielJanete M Cerutti
Sep 25, 2007·Arquivos brasileiros de endocrinologia e metabologia·Erika L Souza MeyerAna Luiza Maia
Nov 14, 2020·Environmental Science & Technology·Christopher D KassotisHeather M Stapleton

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