A tumor suppressor SIRTainty

Cancer Cell
Paul T Schumacker

Abstract

Sirtuin deacetylases are linked to longevity, aging, and stress responses. In this issue of Cancer Cell, Kim et al. show that SIRT3 functions as a tumor suppressor by enhancing the expression of mitochondrial MnSOD. Loss of SIRT3 leads to increased mitochondrial ROS, which then enhances cellular transformation and tumor growth.

References

Aug 22, 2008·Diabetes·Ian R LanzaK Sreekumaran Nair

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Citations

Mar 12, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Chi-Chih LaiMing-Yu Yang
Jun 27, 2013·Molecular Cancer·I-Chieh ChenHung-Che Chiang
Jul 19, 2011·Journal of Aging Research·D McGuinnessP G Shiels
Mar 27, 2015·The Journal of Rural Health : Official Journal of the American Rural Health Association and the National Rural Health Care Association·John R WheatJames D Leeper
Apr 12, 2016·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Yanqin YangZhiying Huang
Sep 13, 2014·Anxiety, Stress, and Coping·Lexine A StapinskiPaul Stallard
Jan 18, 2017·Medicinal Research Reviews·Matthias SchiedelManfred Jung
Feb 13, 2019·Behavioral Sciences·Juan Aníbal González-Rivera, Idania Hernández-Gato
Apr 11, 2019·Waste Management & Research : the Journal of the International Solid Wastes and Public Cleansing Association, ISWA·Ibrahim Aishatu OgiriAlias Radam
Aug 9, 2018·Public Health Nutrition·Rebekah J WalkerLeonard E Egede
Oct 12, 2021·Experimental and Therapeutic Medicine·Keda YangYue Zhu

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