A tumor-targeting Ru/polysaccharide/protein supramolecular assembly with high photodynamic therapy ability

Chemical Communications : Chem Comm
Hong-Guang FuYu Liu

Abstract

Supramolecular assembly with tumor-targeting properties or photodynamic therapy (PDT) ability has recently become a focus of interest in biomaterial field because of its high therapeutic efficacy against tumor cells. Herein, we reported a new type of targeted supramolecular nanoparticles for photodynamic therapy of tumor cells constructed using adamantane-functionalized transferrin protein (Ad-TRF) and a β-cyclodextrin-functionalized ruthenium complex (Ru-HOP-CD), wherein Ad-TRFs acted as the targeted sites for tumor cells, the coordinated Ru(ii) centers acted as the PDT active sites, and the biocompatible polysaccharide β-cyclodextrins acted as the non-covalent linkers. Significantly, the resultant Ru/polysaccharide/protein exhibited not only specific targeting properties towards tumor cells but also high PDT ability under the irradiation of visible light. Furthermore, the assembly showed selective killing towards tumor cells along with negligible toxicity towards normal cells.

References

Jul 6, 2000·Journal of Photochemistry and Photobiology. B, Biology·E DelaeyP de Witte
May 2, 2003·Nature Reviews. Cancer·Dennis E J G J DolmansRakesh K Jain
Sep 15, 2005·Chemical Communications : Chem Comm·Ella Lai-Ming WongNianyong Zhu
Oct 16, 2008·Biochemistry·Cindy A Puckett, Jacqueline K Barton
Jan 30, 2010·Chemical Society Reviews·Yong Chen, Yu Liu
Nov 21, 2013·Journal of Medicinal Chemistry·Yang YangYu Liu
Sep 5, 2014·Dalton Transactions : an International Journal of Inorganic Chemistry·Yongjie ChenXuesong Wang
Feb 27, 2015·Chemical Reviews·Guocan YuFeihe Huang
Mar 27, 2015·Journal of Medicinal Chemistry·Catherine M ClavelPaul J Dyson
Jul 21, 2015·ACS Applied Materials & Interfaces·Wei-Hai ChenXian-Zheng Zhang
Jan 18, 2017·Journal of the American Chemical Society·Sabyasachi ChakraborttyTanja Weil
Aug 4, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Amina Ben MihoubSamir Acherar

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Citations

Jul 17, 2019·Angewandte Chemie·Cinzia ImbertiPeter J Sadler
Nov 19, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Piotr GierlichLígia C Gomes-da-Silva
Jan 23, 2021·Inorganic Chemistry·Ling-Gui LiuHai-Yang Liu
Jan 16, 2020·Bioconjugate Chemistry·Ying WenBradley D Smith
Jun 20, 2020·ACS Medicinal Chemistry Letters·Hong-Guang FuYu Liu

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Methods Mentioned

BETA
fluorescence spectroscopy
transmission
dynamic light scattering
electrophoresis
confocal microscopy
Fluorescence
flow cytometry

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