A tutorial on individual participant data meta-analysis using Bayesian multilevel modeling to estimate alcohol intervention effects across heterogeneous studies

Addictive Behaviors
David HuhDavid C Atkins

Abstract

This paper provides a tutorial companion for the methodological approach implemented in Huh et al. (2015) that overcame two major challenges for individual participant data (IPD) meta-analysis. Specifically, we show how to validly combine data from heterogeneous studies with varying numbers of treatment arms, and how to analyze highly-skewed count outcomes with many zeroes (e.g., alcohol and substance use outcomes) to estimate overall effect sizes. These issues have important implications for the feasibility, applicability, and interpretation of IPD meta-analysis but have received little attention thus far in the applied research literature. We present a Bayesian multilevel modeling approach for combining multi-arm trials (i.e., those with two or more treatment groups) in a distribution-appropriate IPD analysis. Illustrative data come from Project INTEGRATE, an IPD meta-analysis study of brief motivational interventions to reduce excessive alcohol use and related harm among college students. Our approach preserves the original random allocation within studies, combines within-study estimates across all studies, overcomes between-study heterogeneity in trial design (i.e., number of treatment arms) and/or study-level missing data...Continue Reading

References

Jun 21, 2001·Journal of Studies on Alcohol·M E LarimerJ M Cronce
Aug 14, 2001·American Journal of Public Health·J S BaerG A Marlatt
Dec 23, 2004·Journal of Consulting and Clinical Psychology·Kim Fromme, William Corbin
Dec 1, 2006·Prevention Science : the Official Journal of the Society for Prevention Research·Scott T WaltersT Robert Harris
May 2, 2007·Journal of Consulting and Clinical Psychology·Mary E LarimerClayton Neighbors
Feb 27, 2008·Psychology of Addictive Behaviors : Journal of the Society of Psychologists in Addictive Behaviors·Helene Raskin WhiteThomas J Morgan
Jan 28, 2009·Journal of Consulting and Clinical Psychology·Scott T WaltersErnest N Jouriles
Feb 9, 2010·BMJ : British Medical Journal·Richard D RileyGhada Abo-Zaid
Jun 3, 2010·Journal of Consulting and Clinical Psychology·Mark D WoodRosa Carmona-Barros
Sep 9, 2010·Psychology of Addictive Behaviors : Journal of the Society of Psychologists in Addictive Behaviors·Matthew P MartensByron L Zamboanga
Aug 22, 2012·Psychology of Addictive Behaviors : Journal of the Society of Psychologists in Addictive Behaviors·David C AtkinsClayton Neighbors
Apr 10, 2013·International Journal of Epidemiology·Ghassan HamraDavid Richardson
May 21, 2014·Psychology of Addictive Behaviors : Journal of the Society of Psychologists in Addictive Behaviors·Anne E RayUNKNOWN Project INTEGRATE Team
Dec 30, 2014·Psychology of Addictive Behaviors : Journal of the Society of Psychologists in Addictive Behaviors·Eun-Young MunUNKNOWN Project INTEGRATE Team
Apr 29, 2015·JAMA : the Journal of the American Medical Association·Lesley A StewartUNKNOWN PRISMA-IPD Development Group
Jun 21, 2015·Contemporary Clinical Trials·Mark SimmondsLesley Stewart
Jun 9, 2016·Multivariate Behavioral Research·Daniel McNeish, Laura M Stapleton

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Citations

May 21, 2020·Journal of Speech, Language, and Hearing Research : JSLHR·Ethan Weed, Riccardo Fusaroli
Feb 17, 2021·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Eun-Young MunUNKNOWN in Collaboration with Project INTEGRATE Team

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