A twelve-month comparative clinical investigation of two low-dose oral contraceptives containing 20 micrograms ethinylestradiol/75 micrograms gestodene and 20 micrograms ethinylestradiol/150 micrograms desogestrel, with respect to efficacy, cycle control and tolerance

Contraception
J EndrikatB Düsterberg

Abstract

The aim of this study was to compare contraceptive reliability, cycle control and tolerance of an oral contraceptive containing 20 micrograms ethinylestradiol and 75 micrograms gestodene, with a reference preparation containing the same dose of estrogen combined with 150 micrograms desogestrel. This article presents interim data from centers in France and Austria, involving a total of 479 women and 4,991 cycles. Contraceptive reliability was good with both preparations. Two pregnancies occurred in the gestodene group, but neither were due to method failure. In the desogestrel group there were also two pregnancies, of which one was due to method failure. With respect to cycle control, there is a trend towards a lower incidence of intermenstrual bleeding in the gestodene group. The incidence of spotting (scanty bleeding) during the important first three cycles was 3.5% lower in the gestodene group, and over the first six cycles, it was 7.6% lower. Amenorrhea was similar in both groups, but the incidence of dysmenorrhea was significantly lower in the gestodene group (p=0.001). Adverse events were similar in both groups, with headache, breast tension and nausea the most frequently reported symptoms. Body weight remained relatively ...Continue Reading

References

Mar 1, 1994·Advances in Contraception : the Official Journal of the Society for the Advancement of Contraception·C FitzgeraldC Williams

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Citations

Mar 2, 2006·Obstetrics and Gynecology·Alison B EdelmanJeffrey T Jensen
Sep 1, 1994·Advances in Contraception : the Official Journal of the Society for the Advancement of Contraception·N BruyniksI Rákóczi
Jun 15, 1999·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·R C HiteK Brill
Jan 18, 2011·Expert Opinion on Emerging Drugs·Luis BahamondesIlza Monteiro
Feb 26, 1999·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·D Serfaty, M L Vree
Apr 15, 2005·Studies in Family Planning·Virginia J Vitzthum, Karin Ringheim
Feb 1, 2011·Acta Obstetricia Et Gynecologica Scandinavica·Linda EkenrosCecilia Fridén
Mar 15, 2006·Contraception·Rogério Bonassi MachadoEdna Maia
Jun 4, 2002·Best Practice & Research. Clinical Obstetrics & Gynaecology·Rachel E D'Souza, John Guillebaud
Aug 2, 2013·The Cochrane Database of Systematic Reviews·Maria F GalloKenneth F Schulz
Jan 31, 2014·The Cochrane Database of Systematic Reviews·Maria F GalloFrans M Helmerhorst
Dec 18, 2003·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·H P Oosterbaan
Dec 18, 2003·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception
May 6, 2005·Treatments in Endocrinology·Susan J Keam, Antona J Wagstaff

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