A twin study investigating the genetic and environmental aetiologies of parent, teacher and child ratings of autistic-like traits and their overlap.

European Child & Adolescent Psychiatry
Angelica RonaldRobert Plomin

Abstract

In the present study we investigated phenotypic agreement between informants (parent, teacher and child self-report) on ratings of autistic-like traits and compared the genetic and environmental aetiologies of the informants' ratings and of their covariance. Parents and teachers of >2,500 pairs from a community twin sample completed an abbreviated Childhood Asperger Syndrome Test (CAST). The twins also completed an adapted self-report version of the CAST. Structural equation model-fitting was carried out. Correlations between raters were significant but moderate (0.16-0.33). The magnitude of heritability estimates of autistic-like traits varied across raters, being highest for parent-rated autistic-like traits (82-87%) and more modest for child self-reported autistic-like traits (36-47%). Genetic overlap was significant but moderate across all raters. These findings are discussed in relation to population screening for autism and future genetic research.

References

May 1, 1992·Behavior Genetics·J K HewittM Erickson
Dec 1, 1994·Journal of Autism and Developmental Disorders·P SzatmariD L Streiner
Jan 8, 1999·European Child & Adolescent Psychiatry·K KumpulainenI Henttonen
Mar 8, 2000·Journal of Developmental and Behavioral Pediatrics : JDBP·J N ConstantinoR D Todd
Dec 1, 2000·The American Journal of Psychiatry·J N Constantino, R D Todd
Nov 9, 2001·Journal of the American Academy of Child and Adolescent Psychiatry·R Goodman
Mar 29, 2002·Autism : the International Journal of Research and Practice·Fiona J ScottCarol Brayne
May 28, 2002·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Minna HapponenRichard J Rose
Jun 1, 2002·Trends in Cognitive Sciences·Simon Baron-Cohen
Jul 10, 2002·New South Wales Public Health Bulletin·Sarah Thackway, Anton Poder
Mar 22, 2003·Journal of the American Academy of Child and Adolescent Psychiatry·John N ConstantinoRichard D Todd
Jun 1, 2004·Twin Research : the Official Journal of the International Society for Twin Studies·Meike BartelsEdwin J C G van den Oord
Jul 10, 2004·European Child & Adolescent Psychiatry·Andreas BeckerAribert Rothenberger
Dec 25, 2004·Autism : the International Journal of Research and Practice·Jo WilliamsCarol Brayne
Jun 17, 2005·European Child & Adolescent Psychiatry·Jan van der Ende, Frank C Verhulst
Dec 2, 2005·The British Journal of Psychiatry : the Journal of Mental Science·David H SkuseJane Scourfield
Jan 4, 2006·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Dorothy V M BishopJoachim Hallmayer
Jan 21, 2006·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Maj-Britt PosserudChristopher Gillberg
May 25, 2006·Journal of the American Academy of Child and Adolescent Psychiatry·Angelica RonaldRobert Plomin
Aug 16, 2006·Autism : the International Journal of Research and Practice·Jo WilliamsCarol Brayne
Sep 28, 2006·Journal of the American Academy of Child and Adolescent Psychiatry·Angelica RonaldRobert Plomin
Apr 4, 2007·The American Journal of Psychiatry·Jacqueline A DuvallDaniel H Geschwind
Apr 4, 2007·Archives of Pediatrics & Adolescent Medicine·Rosa A HoekstraDorret I Boomsma
Jun 2, 2007·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Bonamy R Oliver, Robert Plomin
Jan 29, 2008·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Angelica RonaldRobert Plomin
Feb 25, 2011·Journal of Autism and Developmental Disorders·Sara MoruzziMarco Battaglia

❮ Previous
Next ❯

Citations

Feb 19, 2011·Journal of Autism and Developmental Disorders·Brooke IngersollM Brent Donnellan
Jan 25, 2012·Journal of Autism and Developmental Disorders·Eva KočovskáChristopher Gillberg
Jun 9, 2012·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Naomi Ornstein Davis, Scott H Kollins
Jul 21, 2010·Molecular Psychiatry·A RonaldP Lichtenstein
Sep 21, 2013·Molecular Autism·Beate St PourcainGeorge Davey Smith
Aug 11, 2011·PloS One·Andrew J O WhitehouseAngelica Ronald
Apr 18, 2012·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Henrik AnckarsäterPaul Lichtenstein
Dec 2, 2009·The British Journal of Psychiatry : the Journal of Mental Science·R A HoekstraA Ronald
Feb 18, 2016·European Child & Adolescent Psychiatry·Nanda N J Rommelse, Catharina A Hartman
Jul 1, 2011·Expert Opinion on Medical Diagnostics·Christine M Freitag
Jul 6, 2015·Hormones and Behavior·Jennifer M JenkinsAriel Knafo-Noam
Apr 29, 2009·Journal of the American Academy of Child and Adolescent Psychiatry·Victoria HallettFrancesca Happé
Jan 19, 2010·International Journal of Law and Psychiatry·Henrik Anckarsäter
Sep 13, 2016·School Mental Health·Gazi AzadDavid S Mandell
Aug 10, 2015·Journal of Communication Disorders·Clare R RogersLaura S DeThorne
Jun 6, 2009·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Pedro M VitalFrancesca Happé
Feb 6, 2009·Depression and Anxiety·Victoria HallettThalia C Eley
May 15, 2012·Autism Research : Official Journal of the International Society for Autism Research·Eric FombonneChristian Diaz Marquez
Feb 18, 2010·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Rosa A HoekstraAngelica Ronald
Dec 17, 2009·Autism Research : Official Journal of the International Society for Autism Research·Carla J DeVincent, Kenneth D Gadow
Jan 30, 2014·Journal of the American Academy of Child and Adolescent Psychiatry·Karla HolmboeAngelica Ronald
Jul 29, 2016·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Charlotte TyeGráinne McLoughlin
May 20, 2017·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Eveline L de ZeeuwDorret I Boomsma
Mar 27, 2018·Clinical Psychological Science : a Journal of the Association for Psychological Science·Elisabeth M Whyte, K Suzanne Scherf
Dec 14, 2017·Translational Psychiatry·Rosa CheesmanRobert Plomin
Aug 25, 2010·Current Opinion in Psychiatry·Giovanni A SalumLuis A P Rohde
Apr 18, 2008·Expert Review of Neurotherapeutics·Angela M Reiersen, Richard D Todd
Mar 28, 2017·Journal of Autism and Developmental Disorders·Nicole StadnickLauren Brookman-Frazee
Mar 26, 2011·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Angelica Ronald, Rosa A Hoekstra
Mar 13, 2019·Molecular Autism·Xiang SunCarol Brayne
Jul 8, 2020·Behavior Genetics·Mark J Taylor, Tinca J C Polderman
Sep 14, 2017·Journal of Autism and Developmental Disorders·Elizabeth ShephardGrainne McLoughlin
Sep 4, 2021·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Roser CañigueralCharlotte Tye
Oct 5, 2021·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Ragna Bugge AskelandAlexandra Havdahl

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asperger Syndrome

Asperger syndrome (AS), also known as Asperger's, is a developmental disorder characterized by significant difficulties in social interaction and nonverbal communication, along with restricted and repetitive patterns of behavior and interests. Discover the latest research on Asperger syndrome here.

Autism

Autism spectrum disorder is associated with challenges with social skills, repetitive behaviors, and often accompanied by sensory sensitivities and medical issues. Here is the latest research on autism.