A Twin Study of Perthes Disease.

Pediatrics
David MetcalfeDaniel C Perry

Abstract

Legg-Calvé-Perthes disease (LCPD) is an idiopathic avascular necrosis of the femoral head. Its etiology is poorly understood, although previous studies have implicated low birth weight and possible genetic determinants. The aim of this study was to identify potential birth weight and genetic associations with LCPD. We extracted all twin pairs from the Danish Twin Registry (DTR) in which at least 1 individual had LCPD. The DTR captures every twin pair born alive in Denmark, and those with LCPD were identified by using health record linkage. Probanwise concordance was calculated to describe the likelihood that any given individual had LCPD if their co-twin was also diagnosed. There were 81 twin pairs: 10 monozygotic, 51 dizygotic, and 20 unclassified (unknown zygosity [UZ]). There was no association between birth weight and being the affected co-twin. Four pairs (2 dizygotic and 2 UZ) were concordant for LCPD, which is greater than would be expected assuming no familial aggregation. There were no concordant monozygotic twin pairs. The overall probandwise concordance was 0.09 (95% confidence interval [CI]: 0.01-0.18): 0.00 for the monozygotic, 0.08 (95% CI: 0.00-0.18) for the dizygotic, and 0.18 (95% CI: 0.00-0.40) for the UZ twin...Continue Reading

References

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Citations

Mar 29, 2019·World Journal of Orthopedics·Vito PavoneGianluca Testa
Nov 24, 2019·Fetal and Pediatric Pathology·Mohammad Javad Akbarian-BafghiHossein Neamatzadeh
Apr 7, 2019·Nature Reviews. Rheumatology·Richard L MeesonAndrew A Pitsillides
May 13, 2020·Calcified Tissue International·J Mark Wilkinson, Eleftheria Zeggini
Feb 27, 2018·Clinical Orthopaedics and Related Research·Yasmin D Hailer, Nils P Hailer

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