PMID: 9174852Apr 1, 1997Paper

A twin study of polycystic ovary syndrome and lipids

Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology
S JahanfarD E Wilcken

Abstract

Our objective was to assess the relative contribution of genetic and environmental factors (particularly androgens) on circulating levels of lipid fractions and to determine the effect, if any, of polycystic ovary syndrome (PCOS) on lipid fractions. The study was carried out in the outpatient clinic of the Royal Hospital for Women, Paddington, Sydney, Australia. A group of 19 monozygotic (MZ) and 15 dizygotic (DZ) twin pairs was identified from the National Twin Register. Ultrasound clinical and biochemical parameters were used to define polycystic ovaries. Serum androgen and lipid fractions were also measured. Eleven pairs of twins (five MZ, six DZ) were scan discordant (i.e. one twin had polycystic ovaries and the co-twin did not). Serum levels of the lipoprotein fractions in twins with polycystic ovaries were not significantly different from the levels found for their co-twins with normal ovaries. There were no significant correlations between androgen-related hormones and any of the lipid measurements. Body mass index (BMI) was positively correlated with triglycerides and lipoprotein (a), and negatively correlated with high-density lipoprotein cholesterol (HDL-C). Sex hormone-binding globulin (SHBG) levels were negatively c...Continue Reading

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Citations

Jul 11, 2009·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Eythimios DeligeoroglouPanagiotis Christopoulos
Dec 18, 2003·Clinical Endocrinology·Tasoula TsilchorozidouGerard S Conway
Aug 9, 2005·Endocrinology and Metabolism Clinics of North America·Paula J Adams Hillard
Jan 26, 2002·American Journal of Obstetrics and Gynecology·Robert A Wild
May 18, 2016·Fertility and Sterility·Michelle R Jones, Mark O Goodarzi
Jan 24, 2007·Nature Clinical Practice. Endocrinology & Metabolism·Margrit Urbanek
Feb 17, 2007·Clinical Obstetrics and Gynecology·Marie Nam Menke, Jerome F Strauss
Jan 10, 2020·The Journal of Clinical Endocrinology and Metabolism·Yoonjung Yoonie JooUNKNOWN International PCOS Consortium
Nov 25, 2004·Endocrine Reviews·Héctor F Escobar-MorrealeJosé L San Millán
Aug 8, 2007·Journal of the Cardiometabolic Syndrome·Khurshid A KhanL Romayne Kurukulasuriya
Feb 15, 2002·Human Fertility : Journal of the British Fertility Society·Katherine F. Michelmore
Aug 3, 2007·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Susmeeta T SharmaJohn E Nestler
Apr 15, 2020·American Journal of Obstetrics and Gynecology·Yanfei ZhangMing Ta Michael Lee

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