A twin study of the trough plasma steady-state concentration of metformin

Pharmacogenetics and Genomics
Tore B StageKim Brosen

Abstract

The aim of this study was to determine the intrapair similarity in trough steady-state plasma concentrations of metformin in monozygotic and dizygotic twin pairs. We included 16 twin pairs (eight monozygotic and eight dizygotic twin pairs) for this study after contacting 524 twin pairs. They were dosed with metformin to steady state (1 g twice daily) for 6 days and on day 7, the trough concentration of metformin was determined 12 h after the last dose. There was no strong intrapair similarity in trough steady-state plasma concentrations of metformin in either dizygotic or monozygotic twin pairs. The trough steady-state plasma concentration of metformin does not appear to be tightly genetically regulated. The interpretation of this finding is limited by the small sample size.

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Citations

Sep 8, 2015·Clinical Pharmacology and Therapeutics·J MatthaeiR Kerb
May 7, 2015·Clinical Pharmacokinetics·Tore Bjerregaard StageMette Marie Hougaard Christensen
May 6, 2015·European Journal of Clinical Pharmacology·Mette Marie Hougaard ChristensenKim Brøsen
Apr 30, 2016·Basic & Clinical Pharmacology & Toxicology·Tore Bjerregaard StageAnton Pottegård
Sep 30, 2018·Basic & Clinical Pharmacology & Toxicology·Tore Bjerregaard StageMaria C Kjellsson
Aug 24, 2017·Basic & Clinical Pharmacology & Toxicology·Andreas J T PedersenMette Marie Hougaard Christensen
Nov 29, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Edyta SutkowskaMariusz G Fleszar
Jun 5, 2021·Scientific Reports·Edyta SutkowskaBernadetta Kaluza

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Methods Mentioned

BETA
pregnancy test
PCR

Clinical Trials Mentioned

NCT01869621

Software Mentioned

GeneMarker
STATA
ECLIPSE2

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