PMID: 11319658Apr 25, 2001Paper

A twin study of weight loss and metabolic efficiency

International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity
V HainerD B Allison

Abstract

To assess the genetic contribution to determinants of therapeutic weight loss in obese female identical twins. Subjects were studied for 40 days on an inpatient unit in three phases: 7 baseline days; 28 days of weight reduction by a very low calorie diet (1.6 MJ per day); and 5 days after weight reduction. Fourteen pairs of premenopausal obese female identical twins (age: 39.0+/-1.7 y; body weight (BW): 93.9+/-21.2 kg; body mass index (BMI): 34.2+/-7.8 kg/m2). : Body composition by hydrodensitometry and resting metabolic rate by indirect calorimetry were assessed before and after weight loss. : There was great variability among pairs in loss of weight (5.9-12.4 kg) and body fat (3.1-12.4 kg). By contrast, the intraclass correlation (ICC) within twin pairs was 0.85, P<0.001 for weight and 0.88, P<0.001 for body fat. A measure of metabolic efficiency, calculated as the difference between 'estimated' and 'measured' energy deficit showed high intrapair correlation (ICC=0.77; P<0.001). The high correlation in metabolic efficiency within twin pairs in response to therapeutic weight loss suggests a strong genetic contribution.

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Citations

Sep 21, 2007·Obesity Surgery·Judith C Hagedorn, John M Morton
Dec 31, 2003·Nutrition·Myles S Faith, Kathleen L Keller
Oct 9, 2002·Neuroscience and Biobehavioral Reviews·John M de Castro, Stephanie Plunkett
Oct 12, 2011·International Journal of Obesity : Journal of the International Association for the Study of Obesity·J NaukkarinenK H Pietiläinen
Nov 14, 2012·International Journal of Obesity : Journal of the International Association for the Study of Obesity·A G Dulloo
Mar 10, 2004·The British Journal of Nutrition·Marleen van Baak
Oct 27, 2004·Zeitschrift für Gerontologie und Geriatrie·P PlatteK M Pirke
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Dec 17, 2008·Obesity·Craig H Warden, Janis S Fisler
Nov 1, 2012·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·A G DullooY Schutz
Sep 19, 2009·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·A Schwartz, E Doucet
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Sep 20, 2006·Expert Opinion on Therapeutic Targets·John C Clapham, Leonard H Storlien
May 23, 2015·Human Molecular Genetics·Jennifer A NettletonPaul W Franks
Jun 12, 2016·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Hiba Shanti, Firas Obeidat
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Oct 12, 2018·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Laura BoswellJosep Vidal

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