A two fatal cases of poisoning involving new cathinone derivative PV8

Legal Medicine
Ewelina PieprzycaMałgorzata Chowaniec

Abstract

α-Pyrrolidinoheptiophenone (PV8) is a representative of α-pyrrolidinophenone derivatives, a new group of synthetic cathinones. PV8 was first detected in illegal products in Japan in 2013. It is closely related to α-pyrrolidinovalerophenone (α-PVP), which was one of the most popular novel psychoactive substance (NPS) in Poland in years 2013-2015. The article presents two cases of fatal poisonings of 36-year-old man and 37-year-old woman, where a new cathinone derivative - PV8 was detected in biological material collected during medicolegal autopsies. The concentration of PV8, measured with LC-MS method, was in the first case - 0.26 µg/mL in blood and 0.11 µg/mL in urine and in the second - 0.07 µg/mL and 0.13 µg/mL, respectively. In both cases medicolegal experts finally have determined that the cause of death was fatal intoxication with the main role of PV8. This substance is another synthetic cathinone which is dangerous for live of the users and requires constant monitoring and further research.

Citations

Apr 7, 2020·Archives of Toxicology·Dino Luethi, Matthias E Liechti
Oct 22, 2020·Medicine, Science, and the Law·Ettore Ferrari JúniorEloisa Dutra Caldas
Dec 3, 2020·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Piotr Adamowicz
Sep 4, 2020·Therapeutic Drug Monitoring·Nunzia La MaidaMarilyn A Huestis
Jan 2, 2021·Forensic Science International : Synergy·Wing-Sum ChanBobbie Kwok-Keung Cheung
Oct 1, 2021·Journal of Analytical Toxicology·Ewelina PieprzycaPiotr Czekaj
Dec 2, 2021·Journal of Analytical Toxicology·Ewelina PieprzycaPiotr Czekaj

❮ Previous
Next ❯

Related Concepts

Related Feeds

Addiction

This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.