PMID: 16641542Apr 28, 2006Paper

A two-generation reproductive toxicity study of butyl benzyl phthalate in rats

The Journal of Toxicological Sciences
Sunao AsoYasusi Minobe

Abstract

A two-generation reproductive toxicity study with extra parameters was performed for Butyl benzyl phthalate (BBP). The compound was administered orally by gavage with the doses of 0, 100, 200, or 400 mg/kg/day to groups of 24 Crj:CD (SD)IGS rats of both sexes to confirm the utility of the protocol for identification of non-steroid chemicals with endocrine activity by ssessing effects on parental animals and offspring. Softening of the testes, diffuse atrophy of testicular seminiferous tubules, decreased spermatozoa and/or residual germ cells in the epididymal lumina were observed in the F1generation after doses more than 100 mg/kg, lowering of the F1 epididymal weights at doses more than 200 mg/kg, along with low F0 epididymal weights, Leydig cell hyperplasia, residual germ cells in the epidimymal lumina, and low seminal vesicle weights, small testes and epididymes, partial aplasia or aplasia of the epididymes, and Leydig cell hyperplasia in the F1 generation with 400 mg/kg. With regard to effects on the reproductive capacity, F1 parents at the dose of 400mg/kg showed a reduced fertility index and delayed preputial separation of the penis. In the offspring, lowered body weights in the F1 case, and change in anogenital distance ...Continue Reading

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Citations

Sep 10, 2015·Toxicological Sciences : an Official Journal of the Society of Toxicology·Kembra L HowdeshellL Earl Gray
Feb 15, 2013·Critical Reviews in Toxicology·Vanessa R KayWarren G Foster
Jun 7, 2014·Critical Reviews in Toxicology·Vanessa R KayWarren G Foster
Dec 3, 2014·General and Comparative Endocrinology·Justine Mathieu-DenoncourtValerie S Langlois
Dec 22, 2014·Reproductive Toxicology·Bart van der BurgBarbara van Vugt-Lussenburg
Nov 30, 2011·International Journal of Toxicology·F Alan Andersen
Jul 21, 2020·Reproductive Medicine and Biology·Aditi SharmaSuks Minhas

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