PMID: 16641543Apr 28, 2006Paper

A two-generation reproductive toxicity study of benzophenone in rats

The Journal of Toxicological Sciences
Nobuhito HoshinoKaname Takahashi

Abstract

The reproductive toxicity of benzophenone (BZP) was evaluated in a two generation test in which male and female Sprague-Dawley (SD) rats, parental (F0) and first generation (F1), were exposed to BZP by feeding diet containing BZP at concentrations of 0 (control), 100, 450 or 2000 ppm. With regard to the effects of BZP on the F0 and F1 parental animals, inhibition of body weight gain and food consumption, significantly elevated renal weights, dilatation of the renal proximal tubules, and regeneration of the proximal tubular epithelium were recognized at doses of 450 ppm and 2000 ppm, along with an increase in hepatic weight and centrilobular hepatocytic hypertrophy, considered as vital adaptive changes, at the doses of 100 ppm or more. Obvious effects on the endocrine system and reproductive toxicological effects were not found even at the dose of 2000 ppm in the F0 or F1 parent. There were no test substance related changes in the estrous cycle, reproductive capability, delivery and lactation, sperm parameters, serum hormone levels, or necropsy findings. As for effects on the offspring, inhibition of body weight gain was observed in both the F1 and F2 males and females of the 2000 ppm group. No effects of BZP treatment were reco...Continue Reading

References

Nov 1, 1991·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·G A BurdockR A Ford

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Citations

Nov 14, 2017·EFSA Journal·UNKNOWN EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF)Wim Mennes
Feb 14, 2020·Journal of Exposure Science & Environmental Epidemiology·Hanne FrederiksenAnna-Maria Andersson

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