PMID: 16641544Apr 28, 2006Paper

A two-generation reproductive toxicity study of 2,4-dichlorophenol in rats

The Journal of Toxicological Sciences
H AoyamaShoji Teramoto

Abstract

A two-generation reproductive toxicity study was conducted with 2,4-dichlorophenol (2,4-DCP), an agent suspected of exerting endocrine disrupting effects. Wistar-Hannover rats, 24/sex/group, were given diet containing 2,4-DCP at dose levels of 0, 500, 2000 or 8000 ppm to examine the potential effects of the test substance on parental animals and their offspring over 2 successive generations. Neither clear systemic nor reproductive toxicity of 2,4-DCP was apparent in the 500 ppm group. In the 2000 ppm group, mean body weight gain and food consumption of females were lowered significantly during the treatment period. Effects on body weights and food consumption were more serious in the 8000 ppm group, both males and females being significantly affected. Reproductive effects of the test substance were also observed in the 2000 and 8000 ppm groups dose-dependently. Observations included significantly increased uterine weights of F1 and/or F2 female weanlings and reduced numbers of implantation sites and live births of F1 parental females. These results suggest that 2,4-DCP has weak reproductive toxicity, possibly based on endocrine activity. However, the basic mechanisms for apparent estrogenic effects of 2,4-DCP remain to be eluci...Continue Reading

References

Nov 1, 1989·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·D E RodwellM D Mercieca
Oct 1, 1995·Environmental Health Perspectives·G M StancelD S Loose-Mitchell
Apr 16, 1998·Reproductive Toxicology·M EmaK Kawashima
Sep 22, 1998·Toxicological Sciences : an Official Journal of the Society of Toxicology·L B BiegelS R Frame
Sep 21, 2001·Environmental Health Perspectives·J KannoUNKNOWN Organisation for Economic Co-operation and Development
May 17, 2002·The Journal of Veterinary Medical Science·Shuji NodaRyoji Yamaguchi
Jun 21, 2002·Toxicological Sciences : an Official Journal of the Society of Toxicology·J OdumJ Ashby
Aug 28, 2002·Congenital Anomalies·Taisen IguchiHideo Kato
Aug 28, 2002·Congenital Anomalies·Taisen IguchiShinsuke Tanabe
Feb 13, 2003·Reproduction : the Official Journal of the Society for the Study of Fertility·Sylvia Curtis Hewitt, Kenneth S Korach
May 6, 2003·Toxicological Sciences : an Official Journal of the Society of Toxicology·George P DastonRobert J Kavlock
Sep 2, 2003·Environmental Health Perspectives·Jun KannoWilliam Owens
Mar 17, 2004·Reproductive Toxicology·Rochelle W TylJohn H Butala
May 12, 2004·Reproductive Toxicology·Ken L TakahashiShoji Teramoto
Aug 1, 1998·Toxicology in Vitro : an International Journal Published in Association with BIBRA·P A JonesL K Earl

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Citations

Aug 28, 2014·Environmental Toxicology·Xiaoning ZhangYingmei Zhang
May 26, 2009·Toxicology Letters·Mandana Ghisari, Eva Cecilie Bonefeld-Jorgensen
May 27, 2008·Bioresource Technology·F Quintanilla-GuerreroC Regalado
Feb 22, 2012·Congenital Anomalies·Hiroaki AoyamaShoji Teramoto
Mar 4, 2014·Mutation Research. Fundamental and Molecular Mechanisms of Mutagenesis·Akira SatoHiroaki Aoyama
Jul 20, 2018·International Journal of Environmental Health Research·Melanie C BuserHana R Pohl
Aug 10, 2018·Environmental and Molecular Mutagenesis·Dejun HuangYongmei Qi
Sep 12, 2007·Nature Biotechnology·Andrew Marshall
Nov 24, 2017·Environmental Toxicology and Pharmacology·Yuhuan ZhangHuili Wang
May 1, 2021·Journal of Cellular Physiology·Xiaoxin DaiBo Zhao
Jun 16, 2012·Environmental Science & Technology·Feng XiaoGuanghao Chen

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