PMID: 16641545Apr 28, 2006Paper

A two-generation reproductive toxicity study of dicyclohexyl phthalate in rats

The Journal of Toxicological Sciences
Nobuhito HoshinoYoshimasa Okazaki

Abstract

The reproductive toxicity of dicyclohexyl phthalate (DCHP) was evaluated in a two generation test in which male and female Sprague-Dawley (SD) rats of parental (F0) and F1 generation were exposed to DCHP in the diet at concentrations of 0 (control), 240, 1200 or 6000 ppm. With regard to the effects on the F0 and F1 parental animals, changes included inhibition of body weight gain and food consumption, diffuse hypertrophy of hepatocytes, and hypertrophy of thyroidal follicular epithelial cells at the doses of 1200 ppm and 6000 ppm. The following changes were observed in the 6000 ppm group: increase weights of the liver and thyroid, increased hyaline droplets in the renal proximal tubular epithelium (F0 and F1 males), reduction of prostatic weight (F1 males), and diffuse and/or focal atrophy of testicular seminiferous tubules (F1 males). In addition, slight prolongation of the estrous cycle was noted in the F0 females of the 6000 ppm group, along with reduced spermatid head counts in the testes (homogenation-resistant spermatids) in F1 male receiving doses of 1200 ppm or 6000 ppm. It is thought that the prolonged estrous cycle was secondary to the suppression of body weight gain. There were no test substance related changes in cl...Continue Reading

References

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Citations

Aug 19, 2008·Environmental Health Perspectives·Mary S WolffAntonia M Calafat
Nov 5, 2008·Biotechnology and Bioengineering·Hui XuMichael L Shuler
Feb 26, 2016·International Journal of Environmental Research and Public Health·Xiaoheng LiRen-Shan Ge
Mar 4, 2015·Journal of Toxicology and Environmental Health. Part a·Jiaqin BaoBo Chen
Feb 15, 2013·Critical Reviews in Toxicology·Vanessa R KayWarren G Foster
Jun 7, 2014·Critical Reviews in Toxicology·Vanessa R KayWarren G Foster
Dec 3, 2014·General and Comparative Endocrinology·Justine Mathieu-DenoncourtValerie S Langlois
Oct 2, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Müfide Aydoğan Ahbab, Nurhayat Barlas
May 30, 2016·Environmental Research·Jessica R ShoaffJoseph M Braun
Oct 30, 2016·Regulatory Toxicology and Pharmacology : RTP·Wolfgang Dekant, James Bridges
Sep 1, 2017·Toxicology and Industrial Health·Müfide Aydogan AhbabNurhayat Barlas
Apr 12, 2007·Journal of Preventive Medicine and Public Health = Yebang Ŭihakhoe Chi·Un-jun HyoungYeon-pyo Hong
Apr 25, 2009·Journal of Applied Toxicology : JAT·Anne-Marie SaillenfaitJean-Philippe Sabaté
May 8, 2013·Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering·Aleksandra TubićRadmila Kovačević

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