A two layers monodomain model of cardiac electrophysiology of the atria

Journal of Mathematical Biology
Yves CoudièreSimon Labarthe

Abstract

Numerical simulations of the cardiac electrophysiology in the atria are often based on the standard bidomain or monodomain equations stated on a two-dimensional manifold. These simulations take advantage of the thinness of the atrial tissue, and their computational cost is reduced, as compared to three-dimensional simulations. However, these models do not take into account the heterogeneities located in the thickness of the tissue, like discontinuities of the fiber direction, although they can be a substrate for atrial arrhythmia (Hocini et al., Circulation 105(20):2442-2448, 2002; Ho et al., Cardiovasc Res 54(2):325-336, 2002; Nattel, Nature 415(6868):219-226, 2002). We investigate a two-dimensional model with two coupled, superimposed layers that allows to introduce three-dimensional heterogeneities, but retains a reasonable computational cost. We introduce the mathematical derivation of this model and error estimates with respect to the three-dimensional model. We give some numerical illustrations of its interest: we numerically show its convergence for vanishing thickness, introduce an optimization process of the coupling coefficient and assess its validity on physiologically relevant geometries. Our model would be an effic...Continue Reading

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Citations

Nov 27, 2018·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Éric Irakoze, Vincent Jacquemet

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