A two-miRNA signature of upregulated miR-185-5p and miR-362-5p as a blood biomarker for breast cancer.

Pathology, Research and Practice
Kai ZhangRong Ma

Abstract

Differentially expressed microRNAs (miRNAs) in the blood of breast cancer patients may serve as diagnostic biomarkers. In this study, miRNA microarray of the blood of breast cancer patients and healthy controls was performed. Candidate differentially expressed miRNAs were further verified by real-time polymerase chain reaction in 68 breast cancer patients and 13 healthy controls. Six upregulated blood miRNAs (miR-26b-5p, miR-106b-5p, miR-142-3p, miR-142-5p, miR-185-5p, and miR-362-5p) were identified in breast cancer patients. These six miRNAs could discriminate breast cancer patients from healthy controls, with areas under the receiver operating characteristic curve (AUCs) of 0.8891, 0.8158, 0.8529, 0.8507, 0.9050, and 0.9333, respectively. Bioinformatic analysis showed that the six miRNAs were potentially involved in numerous cancer-related pathways, including the mitogen-activated protein kinase signaling pathway, nuclear factor-kappa B signaling pathway, and the transforming growth factor-beta signaling pathway. Importantly, two miRNAs (miR-185-5p and miR-362-5p) were used to construct a two-miRNA panel by logistic regression. The two-miRNA panel displayed a better diagnostic performance than each of the miRNAs alone, with ...Continue Reading

References

Oct 27, 2004·PLoS Biology·Bino JohnDebora S Marks
Jun 10, 2005·Nature·Jun LuTodd R Golub
Oct 31, 2006·Trends in Molecular Medicine·Ramiro GarzonCarlo M Croce
Jan 10, 2009·Nature Protocols·Da Wei HuangRichard A Lempicki
Jan 29, 2010·Breast Cancer Research and Treatment·Emad A RakhaIan O Ellis
Nov 10, 2013·Cancer Research·Laoighse MulraneDarran P O'Connor
Jun 4, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·George W SledgeAntonio C Wolff
Aug 13, 2015·ELife·Vikram AgarwalDavid P Bartel
Oct 25, 2016·Current Cancer Drug Targets·Reza SalariniaHamed Mirzaei
Jan 9, 2016·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Jan 11, 2016·Cancer Science·Akihiko ShimomuraTakahiro Ochiya
Jul 2, 2016·Archives of Gynecology and Obstetrics·Ming ZhangXiangnan Li
Jul 28, 2016·Journal of Cancer Research and Therapeutics·Hamed MirzaeiHamid Reza Mirzaei
Oct 27, 2016·Cancer Gene Therapy·S FathullahzadehM Salehi
Oct 16, 2016·Cancer Gene Therapy·M MohammadiH Mirzaei
Nov 3, 2016·Breast Cancer Research and Treatment·András LánczkyBalázs Győrffy
Dec 3, 2016·Oncotarget·Willemijne A M E SchrijverCathy B Moelans
Sep 26, 2017·International Journal of Cancer. Journal International Du Cancer·Christina M WilkeKristian Unger
Oct 2, 2017·Pathology, Research and Practice·Tomasz PowrózekTeresa Małecka-Massalska
Oct 14, 2017·Bioinformatics·Nathan W WongXiaowei Wang
Oct 23, 2018·Journal of Neurochemistry·Pouria KhaniHamed Mirzaei
Oct 1, 2019·International Journal of Cancer. Journal International Du Cancer·Javid Sadri NahandMichael R Hamblin
Sep 8, 2020·Cancer Biomarkers : Section a of Disease Markers·Xuan ZouWei Zhu
Jan 25, 2021·Clinica Chimica Acta; International Journal of Clinical Chemistry·Yudong WuDongming Xing

❮ Previous
Next ❯

Citations

Aug 13, 2021·World Journal of Surgical Oncology·Yu DuLusheng Guo

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.