A two-part mixed-effects modeling framework for analyzing whole-brain network data

NeuroImage
Sean L Simpson, Paul J Laurienti

Abstract

Whole-brain network analyses remain the vanguard in neuroimaging research, coming to prominence within the last decade. Network science approaches have facilitated these analyses and allowed examining the brain as an integrated system. However, statistical methods for modeling and comparing groups of networks have lagged behind. Fusing multivariate statistical approaches with network science presents the best path to develop these methods. Toward this end, we propose a two-part mixed-effects modeling framework that allows modeling both the probability of a connection (presence/absence of an edge) and the strength of a connection if it exists. Models within this framework enable quantifying the relationship between an outcome (e.g., disease status) and connectivity patterns in the brain while reducing spurious correlations through inclusion of confounding covariates. They also enable prediction about an outcome based on connectivity structure and vice versa, simulating networks to gain a better understanding of normal ranges of topological variability, and thresholding networks leveraging group information. Thus, they provide a comprehensive approach to studying system level brain properties to further our understanding of norma...Continue Reading

References

Dec 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·S OgawaD W Tank
Oct 1, 1995·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·B BiswalJ S Hyde
Feb 24, 2006·Journal of Cognitive Neuroscience·Cheryl L GradyGordon Winocur
Jan 26, 2008·Statistics in Medicine·Lei LiuBankole A Johnson
Sep 4, 2008·Neuropsychology·Emily S DarowskiDavid Z Hambrick
Feb 5, 2009·Nature Reviews. Neuroscience·Ed Bullmore, Olaf Sporns
May 6, 2009·Brain Topography·Christina E HugenschmidtPaul J Laurienti
Jun 6, 2009·Current Opinion in Neurology·Danielle S Bassett, Edward T Bullmore
Oct 13, 2009·NeuroImage·Mikail Rubinov, Olaf Sporns
Feb 24, 2010·Proceedings of the National Academy of Sciences of the United States of America·Bharat B BiswalMichael P Milham
Jul 6, 2010·NeuroImage·Andrew ZaleskyEdward T Bullmore
Sep 8, 2010·NeuroImage·Stephen M SmithMark W Woolrich
Nov 10, 2010·PloS One·Bernadette C M van WijkAndreas Daffertshofer
Apr 5, 2011·NeuroImage·Mikail Rubinov, Olaf Sporns
Jun 8, 2011·PloS One·Sean L SimpsonPaul J Laurienti
Aug 11, 2011·PloS One·Cedric E GinestetAndrew Simmons
Oct 13, 2011·Frontiers in Human Neuroscience·Malaak Nasser MoussaPaul J Laurienti
Mar 6, 2012·NeuroImage·Alex FornitoEdward T Bullmore
Jan 1, 2011·Brain Connectivity·Qawi K TelesfordPaul J Laurienti
Jul 24, 2012·Risk Analysis : an Official Publication of the Society for Risk Analysis·Peng SongZhilin Li
Oct 2, 2012·Statistics in Medicine·A James O'Malley
Dec 11, 2013·Frontiers in Computational Neuroscience·Sean L SimpsonPaul J Laurienti
Dec 18, 2013·Developmental Cognitive Neuroscience·Miao CaoYong He
Jan 1, 2012·Electronic Journal of Statistics·Pavel N Krivitsky
Oct 25, 2014·Journal of Applied Statistics·Sean L SimpsonKeith E Muller

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Citations

Jul 22, 2016·Significance·Sean SimpsonPaul Laurienti
Sep 29, 2015·Brain Connectivity·Sean L Simpson, Paul J Laurienti
Jun 13, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Michel Rt SinkeRick M Dijkhuizen
Aug 24, 2019·Human Brain Mapping·Mohsen BahramiSean L Simpson
Feb 23, 2019·Network Neuroscience·Sean L SimpsonPaul J Laurienti
Sep 27, 2018·Human Brain Mapping·Mohsen BahramiSean L Simpson
Sep 12, 2018·Biostatistics·Shuo ChenL Elliot Hong
Jan 23, 2021·Statistics in Medicine·Qiong WuShuo Chen
Jun 8, 2018·NeuroImage·Brian HartUNKNOWN Alzheimer's Disease Neuroimaging Initiative

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