A two-photon antenna for photochemical delivery of nitric oxide from a water-soluble, dye-derivatized iron nitrosyl complex using NIR light

Journal of the American Chemical Society
Stephen R WeckslerPeter C Ford

Abstract

The experiments described here demonstrate the use of two-photon excitation (TPE) to sensitize nitric oxide (NO) release from a dye-derivatized iron/sulfur/nitrosyl cluster Fe2(mu-RS)2(NO)4 (Fluor-RSE, RS = 2-thioethyl ester of fluorescein) with near-infrared (NIR) light in the form of femtosecond pulses from a Ti:sapphire laser. TPE at 800 nm leads both to weak fluorescence from the organic chromophore at lambda(max) = 532 nm and to NO labilization from the cluster. Since the emission from the reference compound Fluor-Et (the ethyl ester of fluorescein) under identical conditions (50/50 CH3CN/phosphate buffer (1 mM) at pH 7.4) is considerably more intense, the weaker emission from Fluor-RSE and the NO generation indicate that the fluorescein excited states initially formed by TPE are largely quenched by energy transfer to the cluster core. The two-photon absorption (TPA) cross section of Fluor-RSE at 800 nm was determined to be delta = 63 +/- 7 GM via the TPA photoluminescence technique. This can be compared to the TPA cross section of 36 GM reported for fluorescein dye in pH 11 aqueous solution and of 32 +/- 3 GM for Fluor-Et measured under conditions comparable to those used for Fluor-RSE. Pulse intensity dependence studies ...Continue Reading

References

Jan 1, 1992·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·T J Dougherty, S L Marcus
Apr 6, 1990·Science·W DenkW W Webb
Oct 17, 1989·European Journal of Pharmacology·J GarthwaiteS Moncada
Sep 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·R IyengarM A Marletta
Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·L J IgnarroG Chaudhuri
Aug 1, 1997·Current Biology : CB·M JaconiD Clapham
Jan 1, 1997·Journal of Clinical Laser Medicine & Surgery·J D BhawalkarP N Prasad
Feb 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·T FurutaR Y Tsien
Dec 7, 2000·Journal of Microscopy·K König
Jul 18, 2001·Journal of the American Chemical Society·P K FrederiksenP R Ogilby
Apr 11, 2002·Chemical Reviews·Anthony R Butler, Ian L Megson
Apr 1, 2003·Inorganic Chemistry·Christa L ConradoPeter C Ford
Nov 30, 1957·Nature·P HOWARD-FLANDERS
Apr 29, 2004·Journal of the American Chemical Society·William R DichtelParas N Prasad
Oct 21, 2004·Journal of the American Chemical Society·Stephen WeckslerPeter C Ford
Dec 14, 2004·Circulation Research·Michael Rubart
May 5, 2005·Journal of the American Chemical Society·Crisjoe A Joseph, Peter C Ford
Aug 17, 2005·Current Topics in Medicinal Chemistry·Christopher M PavlosJohn P Toscano
Aug 18, 2005·Journal of the American Chemical Society·Raymond P BriñasSergei A Vinogradov

❮ Previous
Next ❯

Citations

Sep 1, 2009·Chemical Reviews·Kathryn L Haas, Katherine J Franz
Jul 5, 2007·The Journal of Physical Chemistry. a·Olga S FinikovaSergei A Vinogradov
Aug 30, 2008·Chemical Communications : Chem Comm·Michael J Rose, Pradip K Mascharak
Dec 22, 2009·Dalton Transactions : an International Journal of Inorganic Chemistry·Nicola J FarrerPeter J Sadler
Mar 5, 2011·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Kazuhiro HishikawaNaoki Miyata
May 10, 2007·The Journal of Physical Chemistry. B·Sergei V Lymar, Vladimir Shafirovich
Dec 20, 2011·Nitric Oxide : Biology and Chemistry·Elia TfouniDouglas Wagner Franco
Jan 23, 2016·Journal of Clinical Biochemistry and Nutrition·Hidehiko Nakagawa
Jan 5, 2011·Nitric Oxide : Biology and Chemistry·Hidehiko Nakagawa
Sep 2, 2016·Chemical & Pharmaceutical Bulletin·Hidehiko Nakagawa
Apr 16, 2014·Journal of the American Chemical Society·Naoya IedaHidehiko Nakagawa
Dec 24, 2014·Chemical Communications : Chem Comm·Agustin E PierriPeter C Ford
Aug 6, 2016·Chemical Communications : Chem Comm·Saemi O PoelmaJavier Read de Alaniz
Jan 20, 2011·Angewandte Chemie·Katie L Ciesienski, Katherine J Franz
Dec 20, 2011·Chemistry : a European Journal·Fumika KarakiTomohiko Ohwada
Aug 1, 2007·Dalton Transactions : an International Journal of Inorganic Chemistry·C GirardotC Andraud
Oct 11, 2008·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Edward BeaumontAnny Slama-Schwok
Dec 22, 2009·Dalton Transactions : an International Journal of Inorganic Chemistry·Alexis D Ostrowski, Peter C Ford
Dec 12, 2018·Photochemistry and Photobiology·Alexander Alabugin
Jun 19, 2013·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·John V GarciaPeter C Ford
Jun 2, 2012·Dalton Transactions : an International Journal of Inorganic Chemistry·Anna C MerkleNicolai Lehnert
Sep 26, 2012·Dalton Transactions : an International Journal of Inorganic Chemistry·Peter T Burks, Peter C Ford
Feb 2, 2012·Dalton Transactions : an International Journal of Inorganic Chemistry·Piotr HanczycMarek Samoc
Jan 9, 2021·Free Radical Biology & Medicine·Xiu XuYoujun Yang
May 15, 2009·Journal of the American Chemical Society·Kazuhiro HishikawaNaoki Miyata
Aug 24, 2010·Organic Letters·Reda MhidiaOleg Melnyk
Aug 7, 2021·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Wanjun GongQianjun He
Nov 20, 2013·Journal of the American Chemical Society·Peter T BurksPeter C Ford
May 10, 2011·Journal of the American Chemical Society·Julia H OrtonyGuillermo C Bazan
Sep 11, 2018·Journal of the American Chemical Society·Effie Y ZhouJefferson Chan
Jul 23, 2020·The Journal of Physical Chemistry Letters·Margarita Romero ÁvilaJean-Pierre Malval

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.