A two-stage linkage analysis of Chinese schizophrenia pedigrees in 10 target chromosomes

Biochemical and Biophysical Research Communications
Yonglan ZhengLin He

Abstract

We performed a two-stage linkage scan involving 25 Chinese schizophrenia families, focusing on 10 target chromosomes which have already been the subject of considerable research. We initially genotyped 237 individuals with 186 markers, five candidate regions were then chosen for fine mapping and 49 additional markers were genotyped. In region 1q21-23, a maximum multipoint HLOD (HLOD=2.38) was observed between D1S484 and D1S2705, under the dominant model. In region 5q35, dominant HOLD of 2.36, 2.04, and 2.31 were found at marker D5S2030, D5S408, and D5S2006, respectively. Consistent multipoint results also supported linkage to this region under the same dominant model, with a highest HOLD of 2.47. Furthermore, single-point HLODs (HLOD=1.95 at D22S274, and HLOD=1.91 at D22S1157) were found in region 22q13, under the dominant model. Evidence from these three regions satisfied the criteria for suggestive linkage and should help in identifying schizophrenia susceptibility genes.

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Citations

Aug 1, 2008·Nature·Hreinn StefanssonKari Stefansson
Dec 24, 2010·Experimental & Molecular Medicine·Kyu Young LeeYong Sik Kim
May 27, 2010·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Chun-Ming ChenFu-Chin Liu
Mar 8, 2017·Translational Psychiatry·M ToritsukaK Tanigaki
Mar 23, 2021·Investigative Ophthalmology & Visual Science·Jiaheng XiePatrick T Goodbourn

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