A two-step Notch-dependant mechanism controls the selection of the polar cell pair in Drosophila oogenesis

Development
Caroline VachiasMuriel Grammont

Abstract

Organisers control the patterning and growth of many tissues and organs. Correctly regulating the size of these organisers is crucial for proper differentiation to occur. Organiser activity in the epithelium of the Drosophila ovarian follicle resides in a pair of cells called polar cells. It is known that these two cells are selected from a cluster of equivalent cells. However, the mechanisms responsible for this selection are still unclear. Here, we present evidence that the selection of the two cells is not random but, by contrast, depends on an atypical two-step Notch-dependent mechanism. We show that this sequential process begins when one cell becomes refractory to Notch activation and is selected as the initial polar cell. This cell then produces a Delta signal that induces a high level of Notch activation in one other cell within the cluster. This Notch activity prevents elimination by apoptosis, allowing its selection as the second polar cell. Therefore, the mechanism used to select precisely two cells from among an equivalence group involves an inductive Delta signal that originates from one cell, itself unable to respond to Notch activation, and results in one other cell being selected to adopt the same fate. Given it...Continue Reading

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Citations

Apr 24, 2013·Proceedings of the National Academy of Sciences of the United States of America·Yu-Chiuan ChangDenise J Montell
Feb 15, 2012·Journal of Cell Science·Elena Domanitskaya, Trudi Schüpbach
Jun 18, 2015·Nature Communications·Lathiena A ManningMichelle Starz-Gaiano
Jun 22, 2012·Genetics Research International·Jingxia Xu, Thomas Gridley
Apr 9, 2008·Current Biology : CB·Flora Llense, Enrique Martín-Blanco
May 26, 2017·Cell Death & Disease·Alba Y TorresFrançois Agnès
Mar 6, 2018·PLoS Neglected Tropical Diseases·Chia-Hao ChangShin-Hong Shiao
Dec 12, 2012·Development·Antoine BorensztejnAnne-Marie Pret

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis