A two-year toxicology study of bisphenol A (BPA) in Sprague-Dawley rats: CLARITY-BPA core study results

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Luísa CamachoK B Delclos

Abstract

We report the data from the guideline-compliant two-year toxicology study conducted as part of the Consortium Linking Academic and Regulatory Insights on Bisphenol A Toxicity (CLARITY-BPA). BPA (0, 2.5, 25, 250, 2,500, and 25,000 μg/kg body weight (bw)/day) was administered daily by gavage in 0.3% carboxymethylcellulose vehicle to NCTR Sprague-Dawley rats from gestation day 6 through the start of parturition and then directly to pups from the day after birth until postnatal day 21 (stop-dose arm) or continuously until termination at one or two years. The stop-dose arm was included to assess the potential for any BPA effects that were due to developmental exposure. No BPA-related effects were evident in the in-life and non-histopathology data. Neoplastic and nonneoplastic lesions diagnosed in both females and males were common age-associated lesions that were variable across control and BPA-treated groups. The lack of consistent responses within the continuous- and stop-dose arms within and across tissues brought into question the plausible relationship of most of these lesions to BPA treatment. There was a possible relationship between the increased incidences of lesions in the female reproductive tract and the male pituitary a...Continue Reading

Citations

Jun 3, 2020·Biomedicines·Eleonora Rotondo, Francesco Chiarelli
Dec 10, 2020·Environmental Health Perspectives·Yuet-Kin LeungShuk-Mei Ho
Sep 24, 2020·Endocrinology·Frederick S Vom Saal, Laura N Vandenberg
Feb 3, 2021·Environment International·Véronique SirotMarion Hulin
Jan 31, 2021·Nature Reviews. Endocrinology·Ana M SotoCarlos Sonnenschein
Mar 6, 2021·Environmental Science and Pollution Research International·Nadeem Ghani KhanShama Prasada Kabekkodu
Jan 31, 2021·Endocrinology·Frederick S Vom Saal, Laura N Vandenberg
Mar 4, 2021·Molecular and Cellular Endocrinology·Casandra WalkerMartine Culty
Mar 7, 2021·Antioxidants·Joana SantiagoMargarida Fardilha
Jan 28, 2021·Toxicological Sciences : an Official Journal of the Society of Toxicology·Abishankari RajkumarBarbara F Hales
Jul 20, 2020·Reproductive Toxicology·Jerrold J HeindelR Thomas Zoeller
May 12, 2021·Expert Review of Endocrinology & Metabolism·Laura N Vandenberg

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