PMID: 9445013Jan 28, 1998Paper

A tyrosine-rich region in the N terminus of CCR5 is important for human immunodeficiency virus type 1 entry and mediates an association between gp120 and CCR5

Journal of Virology
M FarzanJ Sodroski

Abstract

Human immunodeficiency virus type 1 (HIV-1) requires the presence of specific chemokine receptors in addition to CD4 to enter target cells. The chemokine receptor CCR5 is used by the macrophage-tropic strains of HIV-1 that predominate during the asymptomatic stages of infection. Here we identify a small tyrosine-rich region of CCR5 proximal to the N-terminal cysteine that is critical for entry of macrophage-tropic and dual-tropic variants of HIV-1. HIV-1 infection of cells expressing CCR5 mutants with changes in this region was substantially reduced compared with the infection of cells bearing wild-type CCR5. Simian immunodeficiency virus (SIVmac239) entry was also ablated on a subset of these mutants but enhanced on others. These differences in virus entry were correlated with the relative ability of soluble, monomeric HIV-1 and SIVmac239 gp120 glycoproteins to bind the CCR5 mutants. These results identify a region of CCR5 that is necessary for the physical association of the gp120 envelope glycoprotein with CCR5 and for HIV-1 infection.

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Citations

Jun 8, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·T LehnerC Kelly
Sep 10, 2002·AIDS·Julio Martín-GarcíaFrancisco González-Scarano
Jul 3, 2003·The Journal of Biological Chemistry·Diana Alvarez AriasStephen C Peiper
Apr 23, 2004·Proteins·Shang-Te D Hsu, Alexandre M J J Bonvin
Nov 1, 2007·The Journal of Biological Chemistry·Kazuaki MondeKeisuke Yusa
Jan 25, 2013·Viruses·Christopher J De Feo, Carol D Weiss
Mar 27, 2013·Antimicrobial Agents and Chemotherapy·Michael A LobritzEric J Arts
Feb 25, 2015·Nature·Matthew R GardnerMichael Farzan
Apr 1, 2015·AIDS Research and Human Retroviruses·Giselle Calasans de Souza CostaLuiz Carlos Junior Alcantara
Nov 11, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alexandre GarinChristophe Combadiere
Feb 28, 2002·Journal of Virology·Daniah A D ThompsonTatjana Dragic
Dec 22, 2007·Molecular Pharmacology·Rama KondruMarianna Dioszegi
Oct 27, 1999·Proceedings of the National Academy of Sciences of the United States of America·A CarfíD C Wiley
Aug 10, 2002·Proceedings of the National Academy of Sciences of the United States of America·Christoph SeibertThomas P Sakmar
Feb 26, 2000·Annual Review of Genetics·H TangF Wong-Staal
Jul 8, 1999·Proceedings of the National Academy of Sciences of the United States of America·K LingG Pei

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