A U-shaped relationship of body mass index on atrial fibrillation recurrence post ablation: A report from the Guangzhou atrial fibrillation ablation registry

EBioMedicine
Hai DengGregory Y H Lip

Abstract

Obesity or overweight is related to worse outcomes in patients with atrial fibrillation (AF) following catheter ablation (CA). The role of being underweight in relation to recurrent arrhythmias post AF ablation is less certain. We conducted a retrospective study to investigate the association of body mass index (BMI) with arrhythmia outcomes in AF patients undergoing CA. In a cohort of 1410 AF patients (mean age 57.2 ± 11.6 years; 68% male) undergoing single CA, the association between BMI and AF ablation outcome was analyzed using BMI as a continuous variable and by four BMI categories (<18.5 kg/m2, 18.5-24 kg/m2, 25-29 kg/m2, and ≥ 30 kg/m2). We observed a positive association between a cut off value of BMI and risk of AF recurrence post AF ablation. BMI ≥26.36 kg/m2 was related to more AF recurrence (c-statistic 0.55, 95%CI 0.51-0.58; P < 0.01) with 50% increased risk of AF recurrence (HR 1.50, 95% CI 1.22-1.86; P < 0.01). Recurrence rates in the four BMI categories were 33.3%, 23.2%, 27.2 and 41.8%, respectively (P < 0.01). Kaplan-Meier analysis showed that BMI categories of <18.5 kg/m2 and ≥ 30 kg/m2 were all associated with more AF recurrence (P = 0.01). Both underweight (HR 1.85, 95%CI 1.12-3.08; P = 0.02) and obesity (H...Continue Reading

Citations

Feb 26, 2020·European Heart Journal. Cardiovascular Pharmacotherapy·Saad JavedGregory Y H Lip
Dec 19, 2019·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Xiao LiuKui Hong
Jul 23, 2019·Circulation Journal : Official Journal of the Japanese Circulation Society·Qiqi WangLiangrong Zheng
Feb 8, 2021·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Shijie ZhuJian Peng
Feb 6, 2021·European Journal of Clinical Investigation·Raymond PranataMuhammad Munawar
Jun 8, 2021·Frontiers in Cardiovascular Medicine·Anna ChudaAgata Bielecka-Dabrowa
Aug 11, 2021·Circulation Journal : Official Journal of the Japanese Circulation Society·Koichi FuruiToyoaki Murohara
Nov 18, 2021·Annual Review of Medicine·Anthony H KashouPeter A Noseworthy

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