A UK-wide trial of the Banff classification of renal transplant pathology in routine diagnostic practice

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
P FurnessK Solez

Abstract

The Banff classification of renal transplant pathology has gained wide support since its introduction in 1993. There have been several studies which have tested its usefulness in the context of research-oriented centres. We sought to evaluate its use in a wider context. We recruited pathologists from all but one of the renal transplant centres in the UK. Sections were circulated from 21 selected, 'difficult' cases, in all of which the clinical question was confirmation or exclusion of acute rejection, and in all of which a definite diagnosis had been obvious from the subsequent clinical course. Participants were asked first to diagnose or exclude acute rejection by their usual approach, then to apply the Banff classification. No clinical information was given beyond the time since engraftment, in order to confine the evaluation to the morphological features present in the sections. At the end of the study the subjective impressions of the participants were sought using a structured questionnaire. Using the Banff classification produced no detectable difference in the number of 'correct' diagnoses when compared with a conventional approach, irrespective of whether the 'correct' diagnosis is based on retrospective clinical inform...Continue Reading

Citations

Jan 5, 2000·Transplantation Proceedings·P N FurnessM Nicholson
Feb 13, 1999·Kidney International·L C RacusenY Yamaguchi
Dec 9, 2000·Transplant International : Official Journal of the European Society for Organ Transplantation·J WaiserH H Neumayer
Jul 13, 2005·Clinical Transplantation·Francisco Veríssimo VeroneseLuiz Felipe Gonçalves
Nov 25, 2003·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Wolfram J JabsPhilip F Halloran
Apr 16, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Philip F HalloranR Chris Bleackley
Jul 11, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·K DahanP Grimbert
Oct 19, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·T F MuellerP F Halloran
Apr 28, 2016·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·S CimenM Molinari

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