A unified Markov chain Monte Carlo framework for mapping multiple quantitative trait loci

Genetics
Nengjun Yi

Abstract

In this article, a unified Markov chain Monte Carlo (MCMC) framework is proposed to identify multiple quantitative trait loci (QTL) for complex traits in experimental designs, based on a composite space representation of the problem that has fixed dimension. The proposed unified approach includes the existing Bayesian QTL mapping methods using reversible jump MCMC algorithm as special cases. We also show that a variety of Bayesian variable selection methods using Gibbs sampling can be applied to the composite model space for mapping multiple QTL. The unified framework not only results in some new algorithms, but also gives useful insight into some of the important factors governing the performance of Gibbs sampling and reversible jump for mapping multiple QTL. Finally, we develop strategies to improve the performance of MCMC algorithms.

References

Oct 27, 1997·American Journal of Human Genetics·S C Heath
Dec 13, 2000·Proceedings of the National Academy of Sciences of the United States of America·S Xu, N Yi
Oct 23, 2001·Genetic Epidemiology·P Uimari, M J Sillanpää
Jun 5, 2002·Trends in Genetics : TIG·Mikko J Sillanpää, Jukka Corander
Jun 21, 2002·Genetical Research·Nengjun Yi, Shizhong Xu

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Citations

Mar 16, 2007·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Hiroyoshi IwataTakeshi Hayashi
Nov 7, 2007·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Huihui LiJiankang Wang
Jan 10, 2009·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Hiroyoshi IwataTakeshi Hayashi
Nov 19, 2009·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Eleni BachlavaSteven J Knapp
Feb 22, 2012·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Shize LiRunqing Yang
Dec 7, 2011·Molecular Genetics and Genomics : MGG·Xiaojing ZhouRunqing Yang
Jul 11, 2009·Genetics Research·Daniel Shriner
Jul 30, 2010·Genetics Research·Xiaojuan MiIsmail Dweikat
Mar 25, 2011·Genetics Research·Nengjun Yi
Mar 24, 2010·Journal of Biopharmaceutical Statistics·Luciano Da Costa e Silva, Zhao-Bang Zeng
Jan 24, 2007·Bioinformatics·Brian S YandellNengjun Yi
Jul 10, 2013·Genetics, Selection, Evolution : GSE·Timo KnürrMikko J Sillanpää
Apr 13, 2010·BMC Proceedings·Klara L VerbylaMichael E Goddard
Sep 17, 2004·Genetics·Mikko J Sillanpää, Madhuchhanda Bhattacharjee
Oct 10, 2006·Genetics·Mikko J Sillanpää, Madhuchhanda Bhattacharjee
Apr 17, 2007·Genetics·Runqing Yang, Shizhong Xu
Jul 31, 2007·Genetics·Meng Chen, Christina Kendziorski
May 29, 2008·Genetics·Nengjun Yi, Shizhong Xu
Aug 12, 2008·Genetics·Samprit BanerjeeNengjun Yi
May 29, 2009·Genetics·William ValdarJonathan Flint
Dec 19, 2014·BMC Proceedings·Wonil Chung, Fei Zou
Jun 14, 2008·International Journal of Plant Genomics·Wei Zou, Zhao-Bang Zeng
Feb 18, 2010·Computational Statistics & Data Analysis·Daniel Shriner, Nengjun Yi

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