A unified multicomponent stress-diffusion model of drug release from non-biodegradable polymeric matrix tablets

Journal of Controlled Release : Official Journal of the Controlled Release Society
Ali SalehiRonald G Larson

Abstract

We propose a new transport model of drug release from hydrophilic polymeric matrices, based on Stefan-Maxwell flux laws for multicomponent transport. Polymer stress is incorporated in the total mixing free energy, which contributes directly to the diffusion driving force while leading to time-dependent boundary conditions at the tablet interface. Given that hydrated matrix tablets are dense multicomponent systems, extended Stefan-Maxwell (ESM) flux laws are adopted to ensure consistency with the Onsager reciprocity principle and the Gibbs-Duhem thermodynamic constraint. The ESM flux law for any given component takes into account the friction exerted by all other species and is invariant with respect to reference velocity, thus satisfying Galilean translational invariance. Our model demonstrates that penetrant-induced plasticization of polymer chains partially or even entirely offsets the steady decline of chemical potential gradients at the tablet-medium interface that drive drug release. Utilizing a Flory-Huggins thermodynamic model, a modified form of the upper convected Maxwell constitutive equation for polymer stress and a Fujita-type dependence of mutual diffusivities on composition, depending on parameters, Fickian, anoma...Continue Reading

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Citations

Jun 22, 2017·International Journal of Pharmaceutics·Diego CaccavoAnette Larsson
Apr 2, 2021·Therapeutic Delivery·Hina ShoukatIrsah Maqbool

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