PMID: 6656276Nov 7, 1983

A unifying concept for carcinogenic risk assessments

Journal of Theoretical Biology
T D JonesP J Walsh

Abstract

Carcinogens influence both the initiation of abnormal cells and the subsequent promotion of such cells into neoplasia. Certain other insults seem limited to the stimulation of cellular proliferation and of carcinogenic potentiation. Common examples include surgical, mechanical, chemical, and temperature wounding of tissue followed by healing. In addition, certain hyperplastic growth induced by some chemicals may also enhance tumorigenesis. We propose that the quantification of carcinogenic potentiation may derive from a common-index-quantity estimated according to enhanced cell proliferation resulting from cytotoxicity or toxic hyperplasia induced by a specific exposure. At this time, it is not possible to define, in a restrictive sense, the molecular events which are critical to potentiation but the processes of cell proliferation resulting from cytotoxicity/hyperplasia seem to serve as indices which contain the necessary (and perhaps several secondary) biological responses. The unique advantage is that cell-culture, animal, and human-level studies can be used to evaluate certain parameters of the mathematical model for an untested treatment protocol or chemical insult suspected to be a cofactor in tumorigenesis. The main thru...Continue Reading

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Citations

Aug 1, 1991·Archives of Environmental Contamination and Toxicology·L R GlassP J Walsh
Jan 1, 1991·Archives of Environmental Contamination and Toxicology·T D JonesJ R Trabalka
Sep 1, 1991·Mutation Research·B N Ames, L S Gold
Nov 21, 1992·Annals of the New York Academy of Sciences·B N Ames, M K Shigenaga
Mar 1, 1988·Risk Analysis : an Official Publication of the Society for Risk Analysis·T D JonesD A Sanders
Aug 1, 1989·Regulatory Toxicology and Pharmacology : RTP·A P WatsonG D Griffin

Related Concepts

Tumor Promoters
Cell Division Phases
Cricetus
Hyperplasia
Malignant Neoplasms

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