A Unifying Mechanism for Mitochondrial Superoxide Production during Ischemia-Reperfusion Injury

Cell Metabolism
Edward T ChouchaniMichael P Murphy

Abstract

Ischemia-reperfusion (IR) injury occurs when blood supply to an organ is disrupted--ischemia--and then restored--reperfusion--leading to a burst of reactive oxygen species (ROS) from mitochondria. It has been tacitly assumed that ROS production during IR is a non-specific consequence of oxygen interacting with dysfunctional mitochondria upon reperfusion. Recently, this view has changed, suggesting that ROS production during IR occurs by a defined mechanism. Here we survey the metabolic factors underlying IR injury and propose a unifying mechanism for its causes that makes sense of the huge amount of disparate data in this area and provides testable hypotheses and new directions for therapies.

References

Jan 15, 1975·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·P W HochachkaG C Whittow
Aug 30, 1990·Biochimica Et Biophysica Acta·A B Kotlyar, A D Vinogradov
Jun 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·R BolliP B McCay
Mar 1, 1985·Archives of Biochemistry and Biophysics·J F TurrensA L Lehninger
Mar 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·J L ZweierM L Weisfeldt
Jul 1, 1972·The Biochemical Journal·A BoverisB Chance
Dec 8, 1972·Science·P W Hochachka, T Mustafa
Sep 19, 2002·The Journal of Biological Chemistry·Julie St-PierreMartin D Brand
Feb 27, 2003·Circulation Journal : Official Journal of the Japanese Circulation Society·Yasuhiro YaguchiHideharu Hayashi
Mar 7, 2003·American Journal of Physiology. Renal Physiology·Babu J Padanilam
Aug 27, 2003·Circulation Journal : Official Journal of the Japanese Circulation Society·Yoshiharu KinugasaChiaki Shigemasa
Nov 1, 1964·Circulation Research·S IMAIR M BERNE
Sep 7, 2004·The Journal of Biological Chemistry·Edward J LesnefskyCharles L Hoppel
May 14, 2005·Free Radical Biology & Medicine·Peter J Crack, Juliet M Taylor
Dec 24, 2005·The Biochemical Journal·Lindsay S BurwellPaul S Brookes
Sep 23, 2006·The Journal of Pharmacology and Experimental Therapeutics·Qun ChenEdward J Lesnefsky
Oct 24, 2006·Trends in Pharmacological Sciences·Vera Adam-Vizi, Christos Chinopoulos
Feb 3, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Andrey Y AbramovMichael R Duchen
Aug 8, 2007·The Journal of Experimental Medicine·Sruti ShivaMark T Gladwin
Sep 15, 2007·The New England Journal of Medicine·Derek M Yellon, Derek J Hausenloy
Sep 20, 2007·Proceedings of the National Academy of Sciences of the United States of America·John W ElrodDavid J Lefer
Oct 25, 2007·The Journal of Biological Chemistry·Alexander Galkin, Salvador Moncada
Dec 7, 2007·The New England Journal of Medicine·Radhakrishnan Ramaraj
Apr 9, 2008·Physiological Reviews·Elizabeth Murphy, Charles Steenbergen
Apr 11, 2008·Physiology·Elizabeth Murphy, Charles Steenbergen
Sep 17, 2008·Biochemical Society Transactions·Judy HirstKenneth R Pryde
Dec 9, 2008·The Biochemical Journal·Michael P Murphy

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Citations

May 20, 2016·Cardiovascular Research·Victoria R PellThomas Krieg
Jul 28, 2016·Mitochondrion·Thomas NietzelMarkus Schwarzländer
Apr 1, 2017·Cell and Tissue Research·Gerd Walz
Mar 23, 2017·Journal of Cardiovascular Pharmacology·Rania HarissehAbdallah Gharib
Jun 21, 2017·Proceedings of the National Academy of Sciences of the United States of America·Lawrence KazakBruce M Spiegelman
Nov 7, 2017·FEBS Letters·Rhoda Stefanatos, Alberto Sanz
Mar 24, 2016·International Journal of Molecular Sciences·Zhen JinLiang-Jun Yan
Oct 27, 2017·International Journal of Molecular Sciences·Marius NistorRené Schiffner
Nov 22, 2017·Antioxidants & Redox Signaling·Leticia Prates RomaBruce Morgan
Aug 25, 2017·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Kenneth R OlsonKarl D Straub
Jul 12, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Philippe BonninChristiane Charriaut-Marlangue
Jun 6, 2018·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·James N Cobley
Jun 7, 2018·Nature Biotechnology·Melanie Senior
Sep 19, 2017·Current Opinion in Organ Transplantation·Andrea SchlegelPhilipp Dutkowski
Nov 2, 2016·The Journal of Experimental Biology·Quentin SchullJean-Patrice Robin
Aug 7, 2017·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Dave Speijer
Jul 28, 2018·Clinical and Experimental Pharmacology & Physiology·Yu IshimotoReiko Inagi
Aug 10, 2018·Aging and Disease·Federica De LazzariMarco Bisaglia
Sep 2, 2018·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Tom DariusMichel Mourad
Nov 6, 2018·Nature Reviews. Drug Discovery·Michael P Murphy, Richard C Hartley
Oct 12, 2018·American Journal of Physiology. Renal Physiology·Sorena LoNirmala Parajuli
Mar 30, 2019·Development, Growth & Differentiation·Kyle Jewhurst, Kelly A McLaughlin
May 3, 2019·Journal of Translational Medicine·Lingfei ZhaoJianghua Chen
May 9, 2019·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Katherine E Mathers, James F Staples
Sep 8, 2016·The Journal of Trauma and Acute Care Surgery·Anne L SlaughterErik D Peltz
Mar 23, 2018·Current Transplantation Reports·Andrea SchlegelPhilipp Dutkowski
Sep 21, 2018·The Journal of Biological Chemistry·Elizabeth C HinchyMichael P Murphy
Aug 20, 2019·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Max T BuchkoJayan Nagendran
Oct 17, 2019·International Journal of Molecular Sciences·Ricardo O S SoaresOrlando Castro-E-Silva
Dec 8, 2019·Journal of Clinical Medicine·Mégane PizzimentiBernard Geny
Jan 7, 2020·Experimental Neurobiology·So Yeong CheonJong Eun Lee

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