A unique antibody gene signature is prevalent in the central nervous system of patients with multiple sclerosis.

Journal of Neuroimmunology
A J LigockiNancy L Monson

Abstract

B cells isolated from the CSF of patients with multiple sclerosis (MS) have a unique accumulation of somatic hypermutation within the B cell receptor, termed the antibody gene signature (AGS). The focus of this study was to investigate whether the AGS could also be detected in MS brain tissue. Genetic analysis of B cells isolated from post-mortem CNS tissue samples from four MS brains demonstrated that signature enriched B cells are present at the site of tissue injury as well as in the circulating CSF.

Citations

May 28, 2013·Trends in Immunology·Sarah B SimmonsJoan M Goverman
May 17, 2014·Seminars in Immunopathology·Markus Krumbholz, Edgar Meinl
Jun 10, 2015·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Jorunn N JohansenTrygve Holmøy
Sep 25, 2015·Annals of Clinical and Translational Neurology·Jack P AntelAmit Bar-Or
Oct 10, 2012·Nature Reviews. Neurology·Markus KrumbholzEdgar Meinl

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