PMID: 16613821Apr 15, 2006Paper

A unique case of a benign adrenocortical tumor with triple secretion of cortisol, androgens, and aldosterone: development of multiple sclerosis after surgical removal of the tumor

Hormones : International Journal of Endocrinology and Metabolism
Athina MarkouGeorge Piaditis

Abstract

We present a 39-year old female with a benign adrenal tumor characterized by autonomous secretion of cortisol, androgens, and aldosterone. The patient presented with a 4-year history of hypertension and severe hirsutism. Baseline investigations revealed elevated testosterone, androstendione, and 17OH progesterone with normal levels of dehydroepi androsterone sulfate. CT of the adrenals revealed a 2.5 x 3.0 cm tumor with characteristics of an adenoma on the left adrenal gland. Pelvic ultrasound was normal. Further investigations revealed suppressed basal ACTH levels, loss of diurnal rhythm of cortisol, and failure to suppress on low dose dexamethasone suppression test, suggesting autonomous cortisol secretion by the tumor. She had an exaggerated response of 17OH progesterone to ACTH, implying reduced 21-hydroxylase activity. An elevated plasma aldosterone concentration to plasma renin activity ratio was suggestive of hyperaldosteronism, which was confirmed by failure of aldosterone to suppress to a formal saline infusion test. Complete clinical and biochemical remission of the disease was observed after left adrenalectomy. Histology confirmed the presence of an adrenocortical adenoma. The patient developed multiple sclerosis 6 m...Continue Reading

Citations

Feb 27, 2010·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Holger S WillenbergWerner A Scherbaum
Jan 31, 2009·Journal of the American Veterinary Medical Association·Marion DesmarchelierIsabelle Langlois
Dec 3, 2016·Journal of Hypertension·Hanna RemdeMarcus Quinkler
Apr 18, 2015·Hormones : International Journal of Endocrinology and Metabolism·George N ZografosGregory Kaltsas

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