A Unique Case of Extraovarian Sex-Cord Stromal Fibrosarcoma, With Subsequent Relapse of Differentiated Sex-Cord Tumor

International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists
Jayson WangMona A El-Bahrawy

Abstract

Primary fibrosarcoma arising from ovarian sex-cord stroma is a very rare neoplasm, with only a few reports in the literature. These tumors have been reported to express inhibin which allows their distinction from fibrosarcomas of soft tissue. Here, we report a case of a fibrosarcoma arising in the broad ligament. Despite being totally separate from the ovary, the tumor was diagnosed as sex-cord stromal type on the basis of inhibin expression. Furthermore, this patient suffered a recurrence of her tumor in the pelvis, which showed both the fibrosarcomatous, as well as other sex-cord elements, confirming the sex-cord stromal differentiation of the sarcoma. To our knowledge, this is the first case of a sex-cord stromal fibrosarcoma arising from an extraovarian site. Furthermore, this is also the first case of a recurrent fibrosarcoma, which showed redifferentiation of the tumor into other sex-cord components.

References

Apr 8, 1999·Journal of Clinical Pathology·W G McCluggageP G Toner
May 18, 2004·The Surgical Clinics of North America·Jin-Woo Park, Orlo H Clark
Jul 10, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nicoletta ColomboAlessandra Insinga
Sep 22, 2007·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Suha DeenRobert H Hammond
May 27, 2008·American Journal of Obstetrics and Gynecology·Abdellatif ChechiaAbdelhamid Koubaa

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Citations

Jan 26, 2018·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Richard Wing-Cheuk Wong, W Glenn McCluggage
Nov 2, 2016·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Rajeev Shah, W Glenn McCluggage

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BETA
hysterectomy
biopsies
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SMA

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