A unique case of Hajdu-Cheney syndrome and squamous cell carcinoma of the anus

Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland
B R PageC R Thomas

Abstract

Hajdu-Cheney syndrome (HCS), first described in 1948 by Hajdu and independently in 1965 by Cheney, is an extremely rare disorder characterized by severe and excessive bone resorption leading to osteoporosis, with a wide range of other systemic complications from connective tissue and bone dysplasia. Currently there are approximately 50 distinct cases reported in the literature. There have been several reports associating polycystic kidneys with HCS and several other connective tissue disorders, suggesting a possibility of a hyperproliferative component to the syndrome. No articles exist in the current literature describing a case of HCS with concurrent carcinoma. Here, we present a case of a 54-year-old nonimmune compromised woman with multiple stigmata of HCS and recently diagnosed anal squamous cell carcinoma. This is a case report of HCS and stage T3N0 squamous cell carcinoma of the anus. This is the first report of a patient with HCS with malignancy. We present a patient with HCS who developed anal squamous cell carcinoma. The mechanism of HCS, which is still unknown, may either make patients more susceptible to carcinoma or may just be a reflection of the normal incidence of anal squamous cell carcinoma given attributable ...Continue Reading

References

Jan 1, 1990·Pediatric Radiology·H B DirenO Dicle
Nov 1, 1965·Archives of Dermatology·J W MaliA A Hamers
Jul 29, 2003·Journal of Magnetic Resonance Imaging : JMRI·Maria Antonietta MosettiRichard C Semelka
Jan 1, 1948·The British Journal of Radiology·N HAJDU, R KAUNTZE

❮ Previous
Next ❯

Citations

Sep 10, 2013·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·Shalini R Gupta, Rajiva Gupta
Mar 17, 2018·Neurology India·Wei LiuJunting Zhang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Related Papers

Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
W ZhaoM Mannstadt
Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics
S GrantI Lund
Journal of Cancer Research and Therapeutics
Milind KumarGoura Kishore Rath
© 2022 Meta ULC. All rights reserved