PMID: 6820382Dec 1, 1982Paper

A unique change of steroid metabolism in rat liver microsomes induced with highly toxic polychlorinated biphenyl(PCB) and polychlorinated dibenzofuran(PCDF)

Journal of Pharmacobio-dynamics
S YoshiharaY Masuda

Abstract

Pretreatments of rats with the highly toxic compounds such as 3,4,5,3',4'-pentachlorobiphenyl(PenCB), and 2,3,7,8-tetrachloro(TCDF) and 2,3,4,7,8-pentachlorodibenzofuran(PenCDF), which are potent 3-methylcholanthrene(MC)-type inducers, increased selectively 7 alpha-hydroxylation, but strongly suppressed 2 alpha-, 6 beta- and 16 alpha-hydroxylations as well as 5 alpha-reduction of progesterone and testosterone in the liver microsomes. This unique change in the metabolic pattern was accompanied by a marked decrease in total metabolism of both steroids and appeared to correlate apparently with their toxic potency. This kind of change was not shown by pretreatments with not only MC itself but also the phenobarbital-type(2,4,5,2',4',5'-hexachlorobiphenyl) and the mixed type PCBs(Kanechlor 400, a PCB mixture with 48% chlorine content), all of which possess only a low acute toxicity. The metabolic change produced by 3,4,5,3',4'-PenCB, 2,3,7,8-TCDF and 2,3,4,7,8-PenCDF might not be due to their stimulatory or inhibitory effects, because when added to the incubation mixture 3,4,5,3',4'-PenCB did not change the metabolic pattern with MC-microsomes to that with 3,4,5,3',4'-PenCB-microsomes. Furthermore, either 2,3,7,8-TCDF or 2,3,4,7,8-Pe...Continue Reading

Citations

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