A unique increase in prefrontal gray matter volume in hoarding disorder compared to obsessive-compulsive disorder

PloS One
Satoshi YamadaShigenobu Kanba

Abstract

Hoarding disorder (HD) is a disease concept newly presented in DSM-5. As far as we know, no studies have examined the structural changes relevant to hoarding by applying the diagnostic criteria of HD in DSM-5. In the present study, we aimed to find abnormalities in gray matter (GM) structures of patients with HD. Seventeen patients who met the DSM-5 criteria for HD, 17 obsessive-compulsive disorder (OCD) patients, and 17 healthy controls (HCs) participated in this study. All participants underwent MRI scanning of the brain by a 3.0-Tesla MRI scanner. In a voxel-based morphometric procedure, preprocessed GM structural images were used to compare the three groups. Thereafter we investigated the correlation between the clinical data (age of onset, symptomatic severity) and GM volume. The HD group showed a significantly increased GM volume compared to the OCD and healthy control groups (p<0.05) in both Brodmann area (BA)10 and BA11. There was no significant difference between OCD and healthy control groups. No significant correlation between the clinical data including age of onset, symptom severity score, and GM volume was observed in HD and OCD groups. The results might help to explain the inconsistency of previous studies. As wi...Continue Reading

References

May 1, 1995·Psychiatry and Clinical Neurosciences·T NakajimaM Hanada
Apr 1, 1996·Behaviour Research and Therapy·R O Frost, T L Hartl
Feb 26, 2000·Neuropsychologia·P W BurgessT Shallice
May 4, 2001·Brain : a Journal of Neurology·P C Fletcher, R N Henson
Oct 3, 2001·The British Journal of Psychiatry : the Journal of Mental Science·J J KimJ S Kwon
Jun 1, 2004·The American Journal of Psychiatry·Sanjaya SaxenaLewis R Baxter
Jun 9, 2004·Archives of General Psychiatry·David Mataix-ColsMary L Phillips
Jul 9, 2004·Archives of General Psychiatry·Jesús PujolJulio Vallejo
Sep 8, 2004·Behaviour Research and Therapy·Randy O FrostJessica Grisham
Sep 25, 2004·Depression and Anxiety·Tamara L HartlCary R Savage
Jun 28, 2005·Biological Psychiatry·Antonio A ValenteGeraldo F Busatto
Sep 13, 2005·Neuropsychologia·Taylor W SchmitzSterling C Johnson
Oct 25, 2006·Neural Networks : the Official Journal of the International Neural Network Society·Michael I PosnerYiYuan Tang
Nov 28, 2006·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Jiro OkudaPaul W Burgess
Mar 8, 2007·Behaviour Research and Therapy·Jessica R GrishamDavid H Barlow
Oct 27, 2007·Science·Etienne Koechlin, Alexandre Hyafil
Feb 28, 2008·Journal of Korean Medical Science·So Young YooJun Soo Kwon
Mar 26, 2010·Depression and Anxiety·David Mataix-ColsSabine Wilhelm
Jun 15, 2010·Behaviour Research and Therapy·Jessica R GrishamRaja Kadib
Sep 18, 2010·Science·Stephen M FlemingGeraint Rees
Jul 6, 2011·Archives of General Psychiatry·Matthew J KemptonSteven C R Williams
Jul 19, 2011·Psychiatry Research·David F TolinMatthew M Kurtz
Oct 28, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Marcelo Queiroz HoexterGeraldo Filho Busatto
Aug 8, 2012·Archives of General Psychiatry·David F TolinGodfrey D Pearlson
Oct 9, 2012·Journal of Psychiatric Research·Pedro G AlvarengaMarcelo Q Hoexter
Nov 14, 2013·The American Journal of Psychiatry·Stella J de WitOdile A van den Heuvel
Aug 16, 2016·Psychiatry Research. Neuroimaging·Christina M HoughCarol A Mathews
Sep 10, 2016·The American Journal of Psychiatry·Premika S W BoedhoeOdile A van den Heuvel

❮ Previous
Next ❯

Citations

Apr 26, 2019·Psychiatry and Clinical Neurosciences·Tomohiro Nakao, Shigenobu Kanba
Aug 15, 2019·Current Psychiatry Reports·Eliza J DavidsonCatherine R Ayers
Feb 3, 2021·BJPsych Open·Luca SacchiAndrea Arighi

❮ Previous
Next ❯

Software Mentioned

Mega
PickAtlas
JMP
Matlab
Automatic Anatomic Labeling ( AAL )
SPM12
Analysis
dcm2nii
DARTEL

Related Concepts

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.