A unique pattern of toxic synthesis in pentitol catabolism: implications for evolution

Journal of Molecular Evolution
G A Scangos, A M Reiner

Abstract

All of our Escherichia coli C mutants blocked in the first step of D-arabitol catabolism (D-arabitol dehydrogenase) became unable to grow in the presence of D-arabitol. We have shown that this sensitivity is eliminated by a defect in the second enzyme of the pathway (D-xylulokinase), leading to a pattern of toxicity and its relief which has not been previously reported. We have found a similar pattern of toxicity and its relief in the closely related ribitol pathway. The evolutionary significance of these findings is discussed.

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Citations

Dec 4, 2010·Applied Microbiology and Biotechnology·Srujana KogantiLu-Kwang Ju
Mar 16, 2011·Biotechnology and Bioengineering·Manoj AgrawalRachel Ruizhen Chen
Feb 26, 2015·Journal of Industrial Microbiology & Biotechnology·Xianghui QiWenjing Sun
Feb 25, 2005·FEMS Microbiology Letters·Young Jae JeonPeter L Rogers
Sep 16, 2008·Journal of Plant Physiology·Isaac Kirubakaran Sundar, Natarajan Sakthivel

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