A unique phenotype of T-cell acute lymphoblastic leukemia in a patient with GATA2 haploinsufficiency

Pediatric Blood & Cancer
Orlando EsparzaKimberly Whelan

Abstract

Germline or acquired mutations involving the GATA-binding protein gene (GATA2) have been linked to a variety of clinical conditions. In addition, patients harboring GATA2 mutations have a striking predisposition to develop myeloid malignancies, such as myelodysplastic syndrome or acute myeloid leukemia, but not acute lymphoblastic leukemia (ALL). We report here a unique occurrence of early T-cell precursor ALL in a young child with GATA2 haploinsufficiency.

References

Apr 11, 2008·Nature·J Jeremiah Bell, Avinash Bhandoola
Jan 17, 2009·The Lancet Oncology·Elaine Coustan-SmithDario Campana
Jan 13, 2012·Nature·Jinghui ZhangCharles G Mullighan
Nov 15, 2013·Blood·Michael A SpinnerSteven M Holland
May 28, 2016·Pediatric Blood & Cancer·Ashley K KoegelVenée N Tubman
Feb 10, 2017·Blood·John D Crispino, Marshall S Horwitz
May 5, 2018·Haematologica·Jean DonadieuUNKNOWN French GATA2 study group

❮ Previous
Next ❯

Related Concepts

Related Feeds

AML: Role of LSD1 by CRISPR (Keystone)

Find the latest rersearrch on the ability of CRISPR-Cas9 mutagenesis to profile the interactions between lysine-specific histone demethylase 1 (LSD1) and chemical inhibitors in the context of acute myeloid leukemia (AML) here.

Acute Myeloid Leukemia

Acute myeloid leukemia (AML) is a clinically and genetically heterogeneous disease with approximately 20,000 cases per year in the United States. AML also accounts for 15-20% of all childhood acute leukemias, while it is responsible for more than half of the leukemic deaths in these patients. Here is the latest research on this disease.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.