A unique porin meditates iron-selective transport through cyanobacterial outer membranes.

Environmental Microbiology
Guo-Wei QiuBao-Sheng Qiu

Abstract

Cyanobacteria are globally important primary producers and nitrogen fixers with high iron demands. Low ambient dissolved iron concentrations in many aquatic environments mean that these organisms must maintain sufficient and selective transport of iron into the cell. However, the nature of iron transport pathways through the cyanobacterial outer membrane remains obscure. Here we present multiple lines of experimental evidence that collectively support the existence of a novel class of substrate-selective iron porin, Slr1908, in the outer membrane of the cyanobacterium Synechocystis sp. PCC 6803. Elemental composition analysis and short-term iron uptake assays with mutants in Slr1908 reveal that this protein is primarily involved in inorganic iron uptake and contributes less to the accumulation of other metals. Homologues of Slr1908 are widely distributed in both freshwater and marine cyanobacteria, most notably in unicellular marine diazotrophs. Complementary experiments with a homologue of Slr1908 in Synechococcus sp. PCC 7002 restored the phenotype of Synechocystis knockdown mutants, showing that this siderophore producing species also possesses a porin with a similar function in Fe transport. The involvement of a substrate-s...Continue Reading

References

Oct 18, 1996·The Journal of Biological Chemistry·V V Bartsevich, H B Pakrasi
Feb 5, 1999·Science·M J Behrenfeld, Z S Kolber
Jul 8, 1999·Plant Molecular Biology·Y O KorshunovaH B Pakrasi
Feb 15, 2000·Journal of Bacteriology·E Hoiczyk, A Hansel
Mar 27, 2001·Nucleic Acids Research·J MrázekS Karlin
Aug 6, 2002·Research in Microbiology·Adam KustkaSergio A Sañudo-Wilhelmy
Dec 11, 2003·Microbiology and Molecular Biology Reviews : MMBR·Hiroshi Nikaido
Feb 21, 2004·Science·Michael FallerGeorg E Schulz
Jul 13, 2004·Plant Physiology·Nir KerenHimadri B Pakrasi
Jan 18, 2006·The Journal of Biological Chemistry·Heedeok HongBert van den Berg
Nov 11, 2008·Nature Reviews. Microbiology·Jean-Marie PagèsMathias Winterhalter
Apr 4, 2009·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Brian M Hopkinson, François M M Morel
Jun 3, 2009·Microbiology and Molecular Biology Reviews : MMBR·D J ScanlanF Partensky
Sep 24, 2009·Chemical Reviews·Moriah Sandy, Alison Butler
Feb 27, 2010·Science·Pia H MoisanderJonathan P Zehr
Oct 19, 2010·Journal of Bacteriology·Christopher M Jones, Michael Niederweis
Jan 21, 2011·Proceedings of the National Academy of Sciences of the United States of America·Mak A SaitoJohn B Waterbury
Jun 17, 2011·Nature Reviews. Microbiology·Jill A SohmDouglas G Capone
Aug 16, 2011·Current Opinion in Microbiology·Wolfgang R Hess
Sep 3, 2011·Environmental Microbiology·Brian M Hopkinson, Katherine A Barbeau
Sep 13, 2011·Environmental Microbiology·Chana KranzlerNir Keren
Apr 25, 2012·Frontiers in Microbiology·Yeala Shaked, Hagar Lis
Jan 2, 2013·Proceedings of the National Academy of Sciences of the United States of America·Patrick M ShihCheryl A Kerfeld
Jan 19, 2013·Molecular Biology and Evolution·Kazutaka Katoh, Daron M Standley
Jul 11, 2014·Nature·Tim M Conway, Seth G John
Oct 29, 2014·The ISME Journal·Hagar LisFrançois M M Morel
Jul 29, 2015·Proceedings of the National Academy of Sciences of the United States of America·Katherine R M MackeyMak A Saito
Jul 7, 2016·The Journal of Biological Chemistry·Yuehui ZhuHimadri B Pakrasi

❮ Previous
Next ❯

Citations

Apr 6, 2021·Environmental Microbiology·Ling-Mei LiuHai-Bo Jiang
Apr 22, 2021·Journal of Microbiology and Biotechnology·Hannah SchätzleEnrico Schleiff
Jun 28, 2021·Trends in Microbiology·Guo-Wei QiuNir Keren

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.