A unique role for Stat5 in recovery from acute anemia

The Journal of Clinical Investigation
Gregory D Longmore

Abstract

The precise role of erythropoietin receptor-activated (EpoR-activated) Stat5 in the regulation of erythropoiesis remains unclear. In this issue of the JCI, Menon and colleagues present new experimental data that indicate a distinct role for Stat5 in the regulation of stress-induced erythropoiesis, such as during acute anemic states (see the related article beginning on page 683). A critical function for Stat5 is to promote cell survival, possibly through transcriptional induction of the antiapoptotic protein Bcl-x. In the present experimental system, erythropoietin-Stat5 signals did not induce Bcl-x expression but did induce oncostatin-M. Moreover, oncostatin-M was found to enhance survival of erythroid progenitors. This work differentiates between steady-state (or homeostatic) erythropoiesis and stress-induced erythropoiesis at the level of EpoR signaling.

References

Jul 14, 1998·Blood Reviews·J Palis, G B Segel
Oct 26, 1999·Cell Structure and Function·M Obinata, N Yanai
Jun 11, 2003·The Journal of Cell Biology·Prithi RajanRonald D G McKay
Dec 14, 2004·Blood·Laurie E LenoxRobert F Paulson
Mar 3, 2006·The Journal of Clinical Investigation·Madhu P MenonDon M Wojchowski

❮ Previous
Next ❯

Citations

Oct 16, 2008·The Journal of Biological Chemistry·Olga BogachevaDon M Wojchowski
Mar 20, 2008·Blood·Pradeep SathyanarayanaDon M Wojchowski
Aug 16, 2018·Frontiers in Oncology·Emira Bousoik, Hamidreza Montazeri Aliabadi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.