A unique therapeutic approach to emesis and itch with a proanthocyanidin-rich genonutrient.

Journal of Translational Medicine
Mark Js MillerKeith A Sharkey

Abstract

We examined the therapeutic potential of a proprietary Croton palanostigma extract (Zangrado(R)) in the management of emesis and itch. Emesis was induced in ferrets with morphine-6-glucuronide (0.05 mg/kg sc) in the presence of Zangrado (3 mg/kg, ip) and the cannabinoid receptor 1 antagonist, AM 251 (5 mg/kg, ip). Topical Zangrado (1%) was assessed for anti-pruretic actions in the 5-HT-induced scratching model in rats and evaluated in capsaicin-induced gastric hyperemia as measured by laser doppler flow. In the ApcMinmouse model of precancerous adenomatosis polyposis, mice received Zangrado (100 mug/ml in drinking water) from the age of 6 - 16 weeks for effects on polyp number. In RAW 264.7 cells Zangrado was examined for effects on lipopolysaccharide-induced nitrite production. Zangrado was a highly effective anti-emetic, reducing morphine-induced vomiting and retching by 77%. These benefits were not associated with sedation or hypothermia and were not reversed by cannabinoid receptor antagonism. Itch responses were blocked in both the morphine and 5-HT models. Zangrado did not exacerbate the ApcMincondition rather health was improved. Capsaicin-induced hyperemia was blocked by Zangrado, which also attenuated the production of...Continue Reading

References

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Citations

Apr 5, 2013·Dermatologic Therapy·F PfabJ Ring
Mar 27, 2013·Journal of Ethnopharmacology·Edson Luis MaistroFabio Ferreira Perazzo
Jul 2, 2011·Biological & Pharmaceutical Bulletin·Qing-Zhong LiKi-Wug Sung

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