A unique wheat disease resistance-like gene governs effector-triggered susceptibility to necrotrophic pathogens.

Proceedings of the National Academy of Sciences of the United States of America
Justin D FarisTimothy L Friesen

Abstract

Plant disease resistance is often conferred by genes with nucleotide binding site (NBS) and leucine-rich repeat (LRR) or serine/threonine protein kinase (S/TPK) domains. Much less is known about mechanisms of susceptibility, particularly to necrotrophic fungal pathogens. The pathogens that cause the diseases tan spot and Stagonospora nodorum blotch on wheat produce effectors (host-selective toxins) that induce susceptibility in wheat lines harboring corresponding toxin sensitivity genes. The effector ToxA is produced by both pathogens, and sensitivity to ToxA is governed by the Tsn1 gene on wheat chromosome arm 5BL. Here, we report the cloning of Tsn1, which was found to have disease resistance gene-like features, including S/TPK and NBS-LRR domains. Mutagenesis revealed that all three domains are required for ToxA sensitivity, and hence disease susceptibility. Tsn1 is unique to ToxA-sensitive genotypes, and insensitive genotypes are null. Sequencing and phylogenetic analysis indicated that Tsn1 arose in the B-genome diploid progenitor of polyploid wheat through a gene-fusion event that gave rise to its unique structure. Although Tsn1 is necessary to mediate ToxA recognition, yeast two-hybrid experiments suggested that the Tsn1...Continue Reading

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Citations

Feb 22, 2012·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Fei XueBaoju Yang
Jul 26, 2013·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Justin D FarisSteven S Xu
Nov 20, 2012·Functional & Integrative Genomics·C FeuilletR Appels
Jan 31, 2013·Nature Communications·Aiping ZhengPing Li
Oct 3, 2012·Journal of Experimental Botany·Dirk BalmerBrigitte Mauch-Mani
Jul 21, 2011·Molecular Plant-microbe Interactions : MPMI·Justin D FarisTimothy L Friesen
Jan 19, 2012·Molecular Plant-microbe Interactions : MPMI·Kar-Chun TanRichard P Oliver
Dec 14, 2012·PloS One·Alexandre Morais do AmaralKim E Hammond-Kosack
Jan 11, 2014·Molecular Plant-microbe Interactions : MPMI·Vivianne G A A Vleeshouwers, Richard P Oliver
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Feb 7, 2014·Molecular Plant-microbe Interactions : MPMI·Scot Hulbert, Michael Pumphrey
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Sep 25, 2012·The New Phytologist·Richard Oliver
Dec 24, 2010·The Plant Journal : for Cell and Molecular Biology·Zengcui ZhangJustin D Faris

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