A universal anti-HIV-1 Tat epitope vaccine that is fully synthetic and self-adjuvanting

Vaccine
Gideon Goldstein, John J Chicca

Abstract

Circulating HIV-1 Tat protein is essential for maintenance of the chronic HIV replication that predicates both HIV transmission and clinical progression to AIDS/death. A synthetic anti-Tat epitope vaccine (TUTI-16) was designed to induce neutralizing antibodies to Tat and, hopefully, provide immunological control of HIV replication. TUTI-16 is composed of (1) a conserved Tat B cell epitope (Tat 4-12), rendered universal by introducing known variant amino acids at variable positions 7, 9 and 12 during solid phase synthesis, (2) a promiscuous T helper sequence and (3) a lipopeptide toll-like receptor 2 (TLR2) agonist. TUTI-16 induced high titer antibodies against all 8 known variants of the Tat epitope.

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Citations

Feb 17, 2011·Immunotherapy·June Myung Kim, Sang Hoon Han
May 21, 2010·Journal of Medicinal Chemistry·Nikunj M ShuklaSunil A David
Aug 18, 2012·Advances in Virology·Luna LiBrian Wigdahl
Jan 1, 2012·Biology·Guillaume Mousseau, Susana Valente

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