A universal infant rotavirus vaccine program in two delivery models: Effectiveness and adverse events following immunization

Human Vaccines & Immunotherapeutics
Carolyn Sanford Mvrvp

Abstract

Rotavirus is the most common cause of diarrhea leading to hospitalization in young children. Rotavirus vaccines are available in Canada but have not been introduced in all provinces. In a controlled trial, 2 study sites (Prince Edward Island and the Capital District Health Authority (District 9, Nova Scotia) introduced universal rotavirus vaccine programs for infants at 2 and 4 months of age beginning 1 December 2010, using public health nurse or general practitioner-delivery models, respectively. A third site (Saint John, NB) served as the non-intervention control setting. Vaccine coverage, rotavirus hospitalizations, intussusception and all-cause diarrhea were monitored. A universal rotavirus vaccine program with >90% coverage was associated with reductions in rotavirus-associated hospitalizations (from a peak of 52.8 hospitalizations/100,000 population to 0 hospitalizations) in infants < 12 months and 1 to < 2 y of age 12 months after program implementation. No apparent reduction occurred in the site with vaccine coverage of < 40%, or in the non-intervention control site. No cases of intussusception were associated with vaccine receipt, and no increase in all-cause diarrhea was observed. A universal infant rotavirus vaccine ...Continue Reading

References

Jul 1, 1983·Journal of Clinical Microbiology·C D BrandtR H Parrott
Dec 27, 2007·The Canadian Journal of Infectious Diseases = Journal Canadien Des Maladies Infectieuses·René-Pierre BuiguesGaston De Serres
Jun 24, 2008·Bulletin of the World Health Organization·J Anthony G Scott
Dec 17, 2008·Journal of Paediatrics and Child Health·Charnchai Panthongviriyakul, Julie E Bines
Apr 8, 2010·Expert Review of Vaccines·Jacqueline E TateUmesh D Parashar
May 15, 2010·The Pediatric Infectious Disease Journal·Nicole Le SauxUNKNOWN Canadian Immunization Monitoring Program, Active (IMPACT)
Apr 22, 2011·Journal of the Royal Society, Interface·Virginia E PitzerBryan T Grenfell
Nov 17, 2012·BMC Infectious Diseases·Andrew McDermidUNKNOWN Members of the Canadian Immunization Monitoring Program, Active
Dec 29, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Manish M PatelVesta Richardson
Jan 8, 2014·Expert Review of Vaccines·Brian RhaUmesh D Parashar
Sep 4, 2014·BMC Public Health·Mitchell ZelmanUNKNOWN Maritime Universal Rotavirus Vaccination Program (MURVP)

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Citations

Oct 16, 2015·Vaccine·Donna M MacDougallUNKNOWN Maritime Universal Rotavirus Vaccination Program (MURVP)
Nov 12, 2016·Human Vaccines & Immunotherapeutics·Steven HawkenShelley L Deeks
Jul 19, 2019·Journal of the Pediatric Infectious Diseases Society·Andi L Shane, Geoffrey A Weinberg

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NCT01273077

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