A universal platform for building molecular logic circuits based on a reconfigurable three-dimensional DNA nanostructure

Chemical Science
Kai-Yu HeShou-Zhuo Yao

Abstract

Molecular logic gates are capable of performing various logic tasks for biomarker detection, disease diagnostics and therapy, and controlling biological progress. Herein, we integrated multiple components of a logic device into a single DNA 3D nano-assembly with a triangular prism structure. Compared with the separate construction of each component in previously reported DNA logic gate systems, such an integrated design strategy made the 3D DNA nanoprism universal for logic gates, it can be reconfigured to execute diverse logic operations. Binary basic logic gates (OR, AND, INHIBIT and XOR), combinatorial gates (INHIBIT-OR), and multi-valued logic gates (ternary INHIBIT gate) were readily achieved by taking this DNA nanoprism as a universal platform. Moreover, a logic gate system for identification of even numbers and odd numbers from natural numbers was established successfully by employing only this single DNA nanoprism and four short single-stranded DNA. The universality of this nanoprism greatly simplified the design of DNA logic gate system. Additionally, this nanoprism was able to perform logic operation steadily in a biological matrix, indicating that this box-like DNA nanostructure applies to logic gates in a complicate...Continue Reading

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Citations

Dec 13, 2018·Chemical Communications : Chem Comm·Yanyan YuHuaping Peng
Dec 24, 2018·Chembiochem : a European Journal of Chemical Biology·Fan LiHao Pei
Feb 16, 2018·Chemistry : a European Journal·Antoine Bader, Scott L Cockroft
Jan 3, 2020·Topics in Current Chemistry·Weiyang TangYizhen Liu
Oct 3, 2017·Chemical Communications : Chem Comm·Kunli ZhaoShouzhuo Yao
Apr 20, 2021·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Hui LvFei Wang
Nov 1, 2016·ACS Applied Materials & Interfaces·Chunyang ZhouErkang Wang
Aug 8, 2018·Analytical Chemistry·Chunrong YangYalin Tang
Aug 26, 2017·Journal of the American Chemical Society·Ruizi PengWeihong Tan
Jul 20, 2018·Journal of the American Chemical Society·Ruizi PengWeihong Tan
Aug 29, 2021·ACS Applied Materials & Interfaces·Liping ZhuXiurong Yang
Jul 28, 2016·ACS Applied Materials & Interfaces·Chunyang ZhouShaojun Dong

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Methods Mentioned

BETA
electrophoresis
FRET
PCR

Software Mentioned

NanoEngineer -
SEQUIN

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