Jul 28, 2012

A universal scaling law determines time reversibility and steady state of substitutions under selection

Theoretical Population Biology
Michael ManhartAlexandre V Morozov


Monomorphic loci evolve through a series of substitutions on a fitness landscape. Understanding how mutation, selection, and genetic drift drive this process, and uncovering the structure of the fitness landscape from genomic data are two major goals of evolutionary theory. Population genetics models of the substitution process have traditionally focused on the weak-selection regime, which is accurately described by diffusion theory. Predictions in this regime can be considered universal in the sense that many population models exhibit equivalent behavior in the diffusion limit. However, a growing number of experimental studies suggest that strong selection plays a key role in some systems, and thus there is a need to understand universal properties of models without a priori assumptions about selection strength. Here we study time reversibility in a general substitution model of a monomorphic haploid population. We show that for any time-reversible population model, such as the Moran process, substitution rates obey an exact scaling law. For several other irreversible models, such as the simple Wright–Fisher process and its extensions, the scaling law is accurate up to selection strengths that are well outside the diffusion re...Continue Reading

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Mentioned in this Paper

Genetic Drift
Moran a
Time Studies
Mutation Abnormality
Biological Evolution

About this Paper

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