A universal trade-off between growth and lag in fluctuating environments.

Nature
Markus BasanUwe Sauer

Abstract

The rate of cell growth is crucial for bacterial fitness and drives the allocation of bacterial resources, affecting, for example, the expression levels of proteins dedicated to metabolism and biosynthesis1,2. It is unclear, however, what ultimately determines growth rates in different environmental conditions. Moreover, increasing evidence suggests that other objectives are also important3-7, such as the rate of physiological adaptation to changing environments8,9. A common challenge for cells is that these objectives cannot be independently optimized, and maximizing one often reduces another. Many such trade-offs have indeed been hypothesized on the basis of qualitative correlative studies8-11. Here we report a trade-off between steady-state growth rate and physiological adaptability in Escherichia coli, observed when a growing culture is abruptly shifted from a preferred carbon source such as glucose to fermentation products such as acetate. These metabolic transitions, common for enteric bacteria, are often accompanied by multi-hour lags before growth resumes. Metabolomic analysis reveals that long lags result from the depletion of key metabolites that follows the sudden reversal in the central carbon flux owing to the impo...Continue Reading

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Citations

Sep 24, 2020·Molecular Systems Biology·Matthias HeinemannUwe Sauer
Mar 19, 2021·Scientific Reports·Chiara Enrico BenaCarla Bosia
Apr 10, 2021·The Journal of Chemical Physics·Yonghyun Song, Changbong Hyeon
Apr 26, 2021·Ecology Letters·Mark WestobySasha G Tetu
Apr 25, 2021·Journal of Inorganic Biochemistry·Kun ChenPanchao Yin
May 28, 2021·Nature Communications·Amir AkbariBernhard O Palsson
May 30, 2021·Nature Communications·Diego Antonio Fernandez FuentesMattia Zampieri
Oct 14, 2021·PLoS Computational Biology·Michael PanEdmund J Crampin
Oct 20, 2021·The FEBS Journal·Diana SerbanescuShiladitya Banerjee
Nov 17, 2021·The New Phytologist·Jelena GodrijanWilliam M Balch

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